Correlation between Prognostic Factors and the Histopathological Response to Neoadjuvant Chemotherapy in Osteosarcoma: A Retrospective Study

Table 2

Univariate analysis of clinical features and laboratory parameters with histopathological response based on Huvos grading system.

Features	Huvos response
		Poor		Good		CI 95%
		n	%	n	%		RR	min	Max
Sex	Male	28	70.0	12	30.0	0.110	0.800	0.621	1.030
	Female	21	87.5	3	12.5
Age	>20 years	15	93.8	1	6.2	0.089	1.324	1.061	1.651
	≤20 years	34	70.8	14	29.2
Length of complaint	>12 weeks	40	85.1	7	14.9	0.016	1.461	1.011	2.556
	≤12 weeks	9	52.9	8	47.1
Tumor site	Distal	33	78.6	9	21.4	0.600	1.080	0.800	1.459
	Proximal	16	72.7	6	27.3
Tumor size (in diameter)	≥10 cm	41	82.0	9	18.0	0.075	1.435	0.895	2.300
	<10 cm	8	57.1	6	42.9
Postneoadjuvant chemotherapy tumor size	Enlarged	45	88.2	6	11.8	<0.001	2.868	1.261	6.521
	Shrunk	4	30.8	9	69.2
Staging	III	18	94.7	1	5.3	0.028	1.375	1.100	1.719
	IIB	31	68.9	14	31.1
Metastasis	Present	18	94.7	1	5.3	0.028	1.375	1.100	1.719
	Not identified	31	68.9	14	31.1
Pathological fracture	Present	6	100.0	0	0.0	0.322	1.349	1.159	1.570
	Not identified	43	74.1	15	13.6
Preneoadjuvant chemotherapy ALP serum level	Increased	24	82.8	5	17.2	0.578	1.073	0.840	1.371
	Normal	27	77.1	8	22.9
Preneoadjuvant chemotherapy LDH serum level	Increased	50	79.4	13	20.6	1.000	0.794	0.700	0.900
	Normal	1	100.0	0	0.0
Postneoadjuvant chemotherapy ALP serum level	Increased	19	79.2	5	20.8	0.703	1.056	0.804	1.386
	Normal	30	75.0	10	25.0
Increase in postneoadjuvant chemotherapy ALP serum level	Increased	18	90.0	2	10.0	0.117	1.277	1.004	1.625
	Decreased	31	70.5	13	29.5
Postneoadjuvant chemotherapy LDH serum level	Increased	48	76.2	15	23.8	1.000	762	0.664	0.875
	Normal	1	100.0	0	0.0
Increase in postneoadjuvant chemotherapy LDH serum level	Increased	26	78.8	7	21.2	0.338	1.145	865	1.515
	Decreased	22	71.0	9	29.0
Neoadjuvant chemotherapy number of cycles	<2 cycles	4	80.0	1	20.0	1.000	1.049	0.662	1.663
	≥2 cycles	45	76.3	14	23.7
Interval towards surgery postneoadjuvant chemotherapy	>4 weeks	27	25.3	6	7.7	0.306	1.153	0.874	1.520
	≤4 weeks	22	71.0	9	29.0
Surgical procedure	Ablation	21	77.8	6	22.2	0.845	1.028	0.783	1.349
	Salvage	28	75.7	9	24.3