The Utility of SOX2 and AGR2 Biomarkers as Early Predictors of Tamoxifen Resistance in ER-Positive Breast Cancer Patients

Table 3

Validity (AUC, sensitivity, and specificity) for SOX2, AGR2 expression, and serum AGR2 level to discriminate between estrogen-sensitive (group 1) and estrogen-resistant (groups 2 and 3).

	AUC		95% C.I	Cut off	Sensitivity	Specificity	PPV	NPV
SOX2 score	0.970	<0.001	0.948–0.993	≤1	100.0	91.0	93.2	100.0
AGR2 score	0.657	<0.001	0.587–0.728	≤0	31.45	100.0	100.0	54.1
Serum AGR2 level	0.979	<0.001	0.957–1.0	≤9	56.45	96.0	94.6	64.0
SOX2 score + AGR2score + serum AGR2 level	0.984	<0.001	0.968–1.0		100.0	96.0	96.9	100.0

AUC: area under a curve. value: probability value. CI: confidence interval, NPV: negative predictive value, and PPV: positive predictive value. Statistically significant at , cut off was chosen according to Youden index.