Prognostic Impact of Tumor Budding on Moroccan Colon Cancer Patients

Table 6

Association between tumor budding and molecular biomarkers.

Variables	Low-grade tumor budding	High-grade tumor budding	value
MSI status			0.005
MSS	42 (70.0%)	37 (92.5%)
MSI	18 (30.0%)	3 (7.5%)
KRAS status
Mutant	14 (23.3%)	17 (42.5%)	0.02
Wild-type	46 (76.7%)	23 (57.5%)
KRAS codon types
Codon 12	7 (50%)	12 (70.6%)	0.05
Codon 13	5 (35.7%)	4 (23.5%)
Codon 146	2 (14.3%)	1 (5.9%)
KRAS codon 12 variants
G12D	1 (14.3%)	10 (83.3%)	0.007
G12C	2 (28.6%)	2 (16.7%)
G12V	2 (28.6%)	0 (0.0%)
G12A	1 (14.3%)	0 (0.0%)
G12R	1 (14.3%)	0 (0.0%)
KRAS codon 13 variants
G13D	4 (80%)	4 (100%)	0.3
G13V	1 (20%)	0 (0.0%)
NRAS gene status			0.4
Mutant	1 (1.7%)	1 (2.5%)
Wild-type	59 (98.3%)	59 (97.5%)