Atherogenic Factors and Their Epigenetic Relationships

Figure 3

Factors such as nutritional status and genotype have been involved in the presence of risk factors, which not only activate biochemical pathways that lead to cellular dysfunction, but also can alter epigenetics tags on DNA and Histone. The sum of epigenetic modifications in the vascular cells will result in an atherosclerotic epigenetic profile. ROS: reactive oxygen species; EC: endothelial cell; SMC: smooth muscle cell; Mo/Ma: monocyte/macrophage.