International Journal of Vascular Medicine
Volume 2010 (2010), Article ID 834060, 10 pages
http://dx.doi.org/10.1155/2010/834060
Review Article
Caffeine's Vascular Mechanisms of Action
Laboratorio de Investigación en Función Vascular, Departamento de Investigaciones, Fundación CardioInfantil—Instituto de Cardiología, Carrera 13b no. 163-85, Torre A, Piso 3., Bogotá, Colombia
Received 6 April 2010; Accepted 30 June 2010
Academic Editor: Raphael Guzman
Copyright © 2010 Darío Echeverri et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Linked References
- La zona cafetera colombiana, August 2009, http://www.elcafedecolombia.com/caficultura/zonacafetera.html.
- R. Viani, “The composition of coffee,” in Caffeine, Coffee and Health, S. Garatini, Ed., pp. 17–41, Raven Press, New York, NY, USA, 1993. View at Google Scholar
- S. Eisenberg, “Looking for the perfect brew,” Science News, vol. 133, pp. 252–253, 1988. View at Google Scholar
- E. López-García, R. M. Van Dam, T. Y. Li, F. Rodriguez-Artalejo, and F. B. Hu, “The relationship of coffee consumption with mortality,” Annals of Internal Medicine, vol. 148, no. 12, pp. 904–914, 2008. View at Google Scholar · View at Scopus
- G. S. Yukawa, M. Mune, H. Otani, Y. Tone, X.-M. Liang, H. Iwahashi, and W. Sakamoto, “Effects of coffee consumption on oxidative susceptibility of low-density lipoproteins and serum lipid levels in humans,” Biochemistry, vol. 69, no. 1, pp. 70–74, 2004. View at Publisher · View at Google Scholar · View at Scopus
- J. Á. Gómez-Ruiz, D. S. Leake, and J. M. Ames, “In vitro antioxidant activity of coffee compounds and their metabolites,” Journal of Agricultural and Food Chemistry, vol. 55, no. 17, pp. 6962–6969, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- S. C. Larsson and A. Wolk, “Coffee consumption and risk of liver cancer: a meta-analysis,” Gastroenterology, vol. 132, no. 5, pp. 1740–1745, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- D. Bolignano, G. Coppolino, A. Barillà, S. Campo, M. Criseo, D. Tripodo, and M. Buemi, “Caffeine and the kidney: what evidence right now?” Journal of Renal Nutrition, vol. 17, no. 4, pp. 225–234, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- J. L. Donovan and C. L. DeVane, “A primer on caffeine pharmacology and its drug interactions in clinical psychopharmacology,” Psychopharmacology Bulletin, vol. 35, no. 3, pp. 30–48, 2001. View at Google Scholar · View at Scopus
- J. J. Barone and H. R. Roberts, “Caffeine consumption,” Food and Chemical Toxicology, vol. 34, no. 1, pp. 119–129, 1996. View at Publisher · View at Google Scholar · View at Scopus
- M. S. Bispo, M. C. C. Veloso, H. L. C. Pinheiro, R. F. S. De Oliveira, J. O. N. Reis, and J. B. D. Andrade, “Simultaneous determination of caffeine, theobromine, and theophylline by high-performance liquid chromatography,” Journal of Chromatographic Science, vol. 40, no. 1, pp. 45–48, 2002. View at Google Scholar · View at Scopus
- G. M. Etherton and M. S. Kochar, “Coffee facts and controversies,” Archives of Family Medicine, vol. 2, no. 3, pp. 317–322, 1993. View at Publisher · View at Google Scholar · View at Scopus
- J. O. Miners and D. J. Birkett, “The use of caffeine as a metabolic probe for human drug metabolizing enzymes,” General Pharmacology, vol. 27, no. 2, pp. 245–249, 1996. View at Publisher · View at Google Scholar · View at Scopus
- J. O. Miners and R. A. McKinnon, “CYP1A,” in Metabolic Drug Interactions, R. H. Levy, K. E. Thummel, W. F. Trager, P. D. Hansten, and M. E. Eichelbaum, Eds., pp. 61–73, Lippincott Williams & Wilkins, New York, NY, USA, 2000. View at Google Scholar
- P. Pardo, Y. A. García, D. Barral, and M. Farré Albaladejo, “Cafeína: Un nutriente, um fármaco, o uma droga de abuso,” Adicciones, vol. 19, no. 3, pp. 225–238, 2007. View at Google Scholar · View at Scopus
- A. Nehlig, “Are we dependent upon coffee and caffeine? A review on human and animal data,” Neuroscience and Biobehavioral Reviews, vol. 23, no. 4, pp. 563–576, 1999. View at Publisher · View at Google Scholar · View at Scopus
- B. B. Fredholm, K. Bättig, J. Holmén, A. Nehlig, and E. E. Zvartau, “Actions of caffeine in the brain with special reference to factors that contribute to its widespread use,” Pharmacological Reviews, vol. 51, no. 1, pp. 83–133, 1999. View at Google Scholar · View at Scopus
- M. J. Arnaud, “Metabolism of caffeine,” in Caffeine, Coffee and Health, S. Garatini, Ed., pp. 43–95, Raven Press, New York, NY, USA, 1993. View at Google Scholar
- A. Z. LaCroix, L. A. Mead, and K.-Y. Liang, “Coffee consumption and the incidence of coronary heart disease,” The New England Journal of Medicine, vol. 315, no. 16, pp. 977–982, 1986. View at Google Scholar · View at Scopus
- P. Happonen, S. Voutilainen, and J. T. Salonen, “Coffee drinking is dose-dependently related to the risk of acute coronary events in middle-aged men,” Journal of Nutrition, vol. 134, no. 9, pp. 2381–2386, 2004. View at Google Scholar · View at Scopus
- L. Rosenberg, J. R. Palmer, J. P. Kelly, D. W. Kaufman, and S. Shapiro, “Coffee drinking and nonfatal myocardial infarction in men under 55 years of age,” American Journal of Epidemiology, vol. 128, no. 3, pp. 570–578, 1988. View at Google Scholar · View at Scopus
- F. Sofi, A. A. Conti, A. M. Gori, M. L. Eliana Luisi, A. Casini, R. Abbate, and G. F. Gensini, “Coffee consumption and risk of coronary heart disease: a meta-analysis,” Nutrition, Metabolism and Cardiovascular Diseases, vol. 17, no. 3, pp. 209–223, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- M. C. Cornelis and A. El-Sohemy, “Coffee, caffeine, and coronary heart disease,” Current Opinion in Clinical Nutrition and Metabolic Care, vol. 10, no. 6, pp. 745–751, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- E. Lopez-Garcia, R. M. Van Dam, and R. M. Van Dam, “Coffee consumption and coronary heart disease in men and women: a prospective cohort study,” Circulation, vol. 113, no. 17, pp. 2045–2053, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- D. M. Grant, B. K. Tang, and W. Kalow, “Variability in caffeine metabolism,” Clinical Pharmacology and Therapeutics, vol. 33, no. 5, pp. 591–602, 1983. View at Google Scholar · View at Scopus
- J. W. Daly, “Caffeine analogs: biomedical impact,” Cellular and Molecular Life Sciences, vol. 64, no. 16, pp. 2153–2169, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- R. Zucchi and S. Ronca-Testoni, “The sarcoplasmic reticulum channel/ryanodine receptor: modulation by endogenous effectors, drugs and disease states,” Pharmacological Reviews, vol. 49, no. 1, pp. 1–51, 1997. View at Google Scholar
- M. Endo, “Calcium release from the sarcoplasmic reticulum,” Physiological Reviews, vol. 57, no. 1, pp. 71–108, 1977. View at Google Scholar
- H. Karaki and B. Weiss, “Calcium release in smooth muscle,” Life Sciences, vol. 42, no. 2, pp. 111–122, 1988. View at Google Scholar
- A. Guerrero, J. J. Singer, and F. S. Fay, “Simultaneous measurement of release and influx into smooth muscle cells in response to caffeine. A novel approach for calculating the fraction of current carried by calcium,” Journal of General Physiology, vol. 104, no. 2, pp. 395–442, 1994. View at Publisher · View at Google Scholar
- R. W. Butcher and E. W. Sutherland, “Adenosine -phosphate in biological materials. I. Purification and properties of cyclic -nucleotide phosphodiesterase and use of this enzyme to characterize adenosine -phosphate in human urine,” The Journal of Biological Chemistry, vol. 237, pp. 1244–1250, 1962. View at Google Scholar
- H. Y. Ahn, H. Karaki, and N. Urakawa, “Inhibitory effects of caffeine on contractions and calcium movement in vascular and intestinal smooth muscle,” British Journal of Pharmacology, vol. 93, no. 2, pp. 267–274, 1988. View at Google Scholar
- Y. Hatano, K. Mizumoto, T. Yoshiyama, M. Yamamoto, and H. Iranami, “Endothelium-dependent and -independent vasodilation of isolated rat aorta induced by caffeine,” American Journal of Physiology, vol. 269, no. 5, part 2, pp. H1679–H1684, 1995. View at Google Scholar
- L. Missiaen, J. B. Parys, H. De Smedt, B. Himpens, and R. Casteels, “Inhibition of inositol trisphosphate-induced calcium release by caffeine is prevented by ATP,” Biochemical Journal, vol. 300, no. 1, pp. 81–84, 1994. View at Google Scholar
- H. Ozaki, H. Kasai, M. Hori, K. Sato, H. Ishihara, and H. Karaki, “Direct inhibition of chicken gizzard smooth muscle contractile apparatus by caffeine,” Naunyn-Schmiedeberg's Archives of Pharmacology, vol. 341, no. 3, pp. 262–267, 1990. View at Google Scholar
- C. M. Rembold, D. A. van Riper, and X.-L. Chen, “Focal [](i) increases detected by aequorin but not by fura-2 in histamine- and caffeine-stimulated swine carotid artery,” Journal of Physiology, vol. 488, no. 3, pp. 549–564, 1995. View at Google Scholar
- C. Martin, C. Dacquet, C. Mironneau, and J. Mirroneau, “Caffeine-induced inhibition of calcium channel current in cultured smooth muscle cells from pregnant rat myometrium,” British Journal of Pharmacology, vol. 98, no. 2, pp. 493–498, 1989. View at Google Scholar
- A. D. Hughes, S. Hering, and T. B. Bolton, “The action of caffeine on inward barium current through voltage-dependent calcium channels in single rabbit ear artery cells,” Pflugers Archiv European Journal of Physiology, vol. 416, no. 4, pp. 462–466, 1990. View at Publisher · View at Google Scholar
- A. Sattin and T. W. Rall, “The effect of adenosine and adenine nucleotides on the cyclic adenosine -phosphate content of guinea pig cerebral cortex slices,” Molecular Pharmacology, vol. 6, no. 1, pp. 13–23, 1970. View at Google Scholar
- T. Umemura, K. Ueda, and K. Ueda, “Effects of acute administration of caffeine on vascular function,” American Journal of Cardiology, vol. 98, no. 11, pp. 1538–1541, 2006. View at Publisher · View at Google Scholar · View at PubMed
- S. P. Tofovic, K. R. Branch, R. D. Oliver, W. D. Magee, and E. K. Jackson, “Caffeine potentiates vasodilator-induced renin release,” Journal of Pharmacology and Experimental Therapeutics, vol. 256, no. 3, pp. 850–860, 1991. View at Google Scholar
- E. K. Jackson, “Adenosine: a physiological brake on renin release,” Annual Review of Pharmacology and Toxicology, vol. 31, pp. 1–35, 1991. View at Google Scholar
- R. Corti, C. Binggeli, and C. Binggeli, “Coffee acutely increases sympathetic nerve activity and blood pressure independently of caffeine content role of habitual versus nonhabitual drinking,” Circulation, vol. 106, no. 23, pp. 2935–2940, 2002. View at Publisher · View at Google Scholar
- D. Robertson, J. C. Froelich, R. K. Carr et al., “Effects of caffeine on plasma renin activity, catecholamines and blood pressure,” The New England Journal of Medicine, vol. 298, no. 4, pp. 181–186, 1978. View at Google Scholar
- I. Sudano, L. E. Spieker, F. Hermann, A. Flammer, R. Corti, G. Noll, and T. F. Lüscher, “Protection of endothelial function: targets for nutritional and pharmacological interventions,” Journal of Cardiovascular Pharmacology, vol. 47, no. 2, pp. S136–S150, 2006. View at Publisher · View at Google Scholar
- J. P. López, “Fisiología del endotelio vascular,” in Bioquímica del Endotelio Vascular: Implicaciones Fisiológicas y Clínicas, P. López-Jaramillo, Ed., pp. 41–58, Horizonte Impresores, Bogotá, Colombia, 5th edition, 2001. View at Google Scholar
- D. B. Kim-Shapiro, A. N. Schechter, and M. T. Gladwin, “Unraveling the reactions of nitric oxide, nitrite, and hemoglobin in physiology and therapeutics,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 26, no. 4, pp. 697–705, 2006. View at Publisher · View at Google Scholar · View at PubMed
- I. Fleming and R. Busse, “Signal transduction of eNOS activation,” Cardiovascular Research, vol. 43, no. 3, pp. 532–541, 1999. View at Publisher · View at Google Scholar
- X. Wang, F. Lau, L. Li, A. Yoshikawa, and C. Van Breemen, “Acetylcholine-sensitive intracellular store in fresh endothelial cells and evidence for ryanodine receptors,” Circulation Research, vol. 77, no. 1, pp. 37–42, 1995. View at Google Scholar
- F. P. Leung, L. M. Yung, X. Yao, I. Laher, and Y. Huang, “Store-operated calcium entry in vascular smooth muscle,” British Journal of Pharmacology, vol. 153, no. 5, pp. 846–857, 2008. View at Publisher · View at Google Scholar · View at PubMed
- W. S. Shin, H. Kawaguchi, T. Sasaki, Y. P. Wang, W. D. Yang, M. Inukai, and T. Toyo-Oka, “The role of nitric oxide in the cardiovascular system,” Annals of the New York Academy of Sciences, vol. 786, pp. 233–244, 1996. View at Google Scholar
- D. Echeverri, L. Buitrago, A. Delgadillo, M. Beltrán, and F. Montes, “In-vitro vasodilator effect of caffeine in atherosclerotic aorta rabbits,” Clinica e Investigacion en Arteriosclerosis, vol. 20, no. 2, pp. 41–47, 2008. View at Publisher · View at Google Scholar
- C. Watanabe, H. Yamamoto, K. Hirano, S. Kobayashi, and H. Kanaide, “Mechanisms of caffeine-induced contraction and relaxation of rat aortic smooth muscle,” Journal of Physiology, vol. 456, pp. 193–213, 1992. View at Google Scholar
- L. Buitrago, G. Barrera, C. Zuñiga, D. Acosta, F. Montes, and D. Echeverri, “Podría tener la cafeína algún efecto vasculoprotector,” Revista Colombiana de Cardiología, vol. 11, no. 5, pp. 259–260, 2004. View at Google Scholar
- K. Sato, H. Ozaki, and H. Karaki, “Changes in cytosolic calcium level in vascular smooth muscle strip measured simultaneously with contraction using fluorescent calcium indicator fura 2,” Journal of Pharmacology and Experimental Therapeutics, vol. 246, no. 1, pp. 294–300, 1988. View at Google Scholar
- H. Ozaki, T. Ohyama, K. Sato, and H. Karaki, “-dependent and independent mechanisms of sustained contraction in vascular smooth muscle of rat aorta,” Japanese Journal of Pharmacology, vol. 52, no. 3, pp. 509–512, 1990. View at Google Scholar
- P. A. A. Leijten and C. van Breemen, “The effects of caffeine on the noradrenaline-sensitive calcium store in rabbit aorta,” Journal of Physiology, vol. 357, pp. 327–339, 1984. View at Google Scholar
- A. Nakamura, C. Xie, and C. Xie, “Role of non-kinase activity of myosin light-chain kinase in regulating smooth muscle contraction, a review dedicated to Dr. Setsuro Ebashi,” Biochemical and Biophysical Research Communications, vol. 369, no. 1, pp. 135–143, 2008. View at Publisher · View at Google Scholar · View at PubMed
- C. van Breemen, Q. Chen, and I. Laher, “Superficial buffer barrier function of smooth muscle sarcoplasmic reticulum,” Trends in Pharmacological Sciences, vol. 16, no. 3, pp. 98–105, 1995. View at Publisher · View at Google Scholar
- H. Karaki, H. Ozaki, and H. Ozaki, “Calcium movements, distribution, and functions in smooth muscle,” Pharmacological Reviews, vol. 49, no. 2, pp. 157–230, 1997. View at Google Scholar
- S. L. Sandow, R. E. Haddock, C. E. Hill, P. S. Chadha, P. M. Kerr, D. G. Welsh, and F. Plane, “What's where and why at a vascular myoendothelial microdomain signalling complex,” Clinical and Experimental Pharmacology and Physiology, vol. 36, no. 1, pp. 67–76, 2009. View at Publisher · View at Google Scholar · View at PubMed
- H. K. Surks, N. Mochizuki, and N. Mochizuki, “Regulation of myosin phosphatase by a specific interaction with cGMP-dependent protein kinase Iα,” Science, vol. 286, no. 5444, pp. 1583–1587, 1999. View at Publisher · View at Google Scholar
- V. Ralevic and G. Burnstock, “Receptors for purines and pyrimidines,” Pharmacological Reviews, vol. 50, no. 3, pp. 413–492, 1998. View at Google Scholar
- L. A. Conlay, J. A. Conant, F. DeBros, and R. Wurtman, “Caffeine alters plasma adenosine levels,” Nature, vol. 389, no. 6647, p. 136, 1997. View at Publisher · View at Google Scholar · View at PubMed
- I. Biaggioni, B. Olafsson, R. M. Robertson, A. S. Hollister, and D. Robertson, “Cardiovascular and respiratory effects of adenosine in conscious man. Evidence for chemoreceptor activation,” Circulation Research, vol. 61, no. 6, pp. 779–786, 1987. View at Google Scholar
- R. M. Green and G. L. Stiles, “Chronic caffeine ingestion sensitizes the A1 adenosine receptor-adenylate cyclase system in rat cerebral cortex,” Journal of Clinical Investigation, vol. 77, no. 1, pp. 222–227, 1986. View at Google Scholar
- S. H. Jee, J. He, P. K. Whelton, I. Suh, and M. J. Klag, “The effect of chronic coffee drinking on blood pressure: a meta-analysis of controlled clinical trials,” Hypertension, vol. 33, no. 2, pp. 647–652, 1999. View at Google Scholar
- R. R. Griffiths and P. P. Woodson, “Caffeine physical dependence: a review of human and laboratory animal studies,” Psychopharmacology, vol. 94, no. 4, pp. 437–451, 1988. View at Google Scholar
- Y. Zhang and J. N. Wells, “The effects of chronic caffeine administration on peripheral adenosine receptors,” Journal of Pharmacology and Experimental Therapeutics, vol. 254, no. 3, pp. 757–763, 1990. View at Google Scholar
- I. Biaggioni, S. Paul, A. Puckett, and C. Arzubiaga, “Caffeine and theophylline as adenosine receptor antagonists in humans,” Journal of Pharmacology and Experimental Therapeutics, vol. 258, no. 2, pp. 588–93, 1991. View at Google Scholar
- G. A. Rongen, S. C. Brooks, S.-I. Ando, C. F. Notarius, and J. S. Floras, “Caffeine abstinence augments the systolic blood pressure response to adenosine in humans,” American Journal of Cardiology, vol. 81, no. 11, pp. 1382–1385, 1998. View at Publisher · View at Google Scholar
- R. Guieu, C. Devaux, and C. Devaux, “Adenosine and migraine,” Canadian Journal of Neurological Sciences, vol. 25, no. 1, pp. 55–58, 1998. View at Google Scholar
- A. I. Scher, W. F. Stewart, and R. B. Lipton, “Caffeine as a risk factor for chronic daily headache: a population-based study,” Neurology, vol. 63, no. 11, pp. 2022–2027, 2004. View at Google Scholar
- P. Smits, T. Thien, and A. Van 't Laar, “The cardiovascular effects of regular and decaffeinated coffee,” British Journal of Clinical Pharmacology, vol. 19, no. 6, pp. 852–854, 1985. View at Google Scholar
- J. R. Mort and H. R. Kruse, “Timing of blood pressure measurement related to caffeine consumption,” Annals of Pharmacotherapy, vol. 42, no. 1, pp. 105–110, 2007. View at Publisher · View at Google Scholar · View at PubMed
- J. D. Lane, C. F. Pieper, B. G. Phillips-Bute, J. E. Bryant, and C. M. Kuhn, “Caffeine affects cardiovascular and neuroendocrine activation at work and home,” Psychosomatic Medicine, vol. 64, no. 4, pp. 595–603, 2002. View at Publisher · View at Google Scholar
- K. Varani, F. Portaluppi, S. Merighi, E. Ongini, L. Belardinelli, and P. A. Borea, “Caffeine alters A(2A) adenosine receptors and their function in human platelets,” Circulation, vol. 99, no. 19, pp. 2499–2502, 1999. View at Google Scholar
- G. Hibino, T. Moritani, T. Kawada, and T. Fushiki, “Caffeine enhances modulation of parasympathetic nerve activity in humans: quantification using power spectral analysis,” Journal of Nutrition, vol. 127, no. 7, pp. 1422–1427, 1997. View at Google Scholar
- S. P. Tofovic, H. Kusaka, C. A. Pfeifer, and E. K. Jackson, “Central effects of caffeine on renal renin secretion and norepinephrine spillover,” Journal of Cardiovascular Pharmacology, vol. 28, no. 2, pp. 302–313, 1996. View at Publisher · View at Google Scholar
- A. Ohnishi, R. A. Branch, and K. Jackson, “Chronic caffeine administration exacerbates renovascular, but not genetic, hypertension in rats,” Journal of Clinical Investigation, vol. 78, no. 4, pp. 1045–1050, 1986. View at Google Scholar · View at Scopus
- T. K. A. Wierema, A. J. H. M. Houben, and A. J. H. M. Houben, “Mechanisms of adenosine-induced renal vasodilatation in hypertensive patients,” Journal of Hypertension, vol. 23, no. 9, pp. 1731–1736, 2005. View at Google Scholar · View at Scopus