Layperson-Oriented versus Clinical-Based Models for Assessing 10-Year Incidence of Coronary Heart Disease: National FINRISK Study

Table 3

Regression coefficients (𝛽) and hazard ratio (HR) for incident coronary heart disease estimated based on different Cox models.

	Men (𝑛=14815)		Women (𝑛=16617)
	𝛽	HR (95% CI)	𝛽	HR (95% CI)
Laboratory based
Age*, year	3.893	49.07 (35.25–68.32)	4.972	144.38 (78.41–265.82)
Current smoking	0.579	1.78 (1.58–2.01)	0.930	2.53 (2.04–3.15)
History of diabetes	0.950	2.59 (1.99–3.36)	1.185	3.271 (2.33–4.59)
History of hypertension	0.207	1.23 (1.06–1.42)	0.536	1.71 (1.41–2.06)
Incapable of walking 500 meters	0.429	1.54 (1.17–2.01)	0.586	1.80 (1.32–2.45)
Parent(s) with myocardial infarction	0.223	1.25 (1.10–1.42)	0.438	1.55 (1.30–1.85)
Systolic blood pressure*, mmHg	1.491	4.44 (2.74–7.21)	1.933	6.91 (3.66–13.05)
Cholesterol to HDL-C ratio*	1.078	2.94 (2.43–3.55)	0.998	2.71 (2.08–3.54)
Baseline survival function at 10 years
Cohort 1982	0.978		0.997
Cohort 1987	0.979		0.996
Cohort 1992	0.981		0.997
Cohort 1997–2002	0.984		0.996
Non-laboratory based
Age*, year	4.012	55.23 (39.76–76.73)	5.256	191.79 (104.26–352.80)
Current smoking	0.630	1.88 (1.66–2.12)	0.956	2.60 (2.10–3.23)
History of diabetes	0.952	2.59 (1.99–3.36)	1.282	3.60 (2.59–5.02)
History of hypertension	0.219	1.24 (1.07–1.44)	0.575	1.78 (1.47–2.14)
Incapable of walking 500 meters	0.480	1.62 (1.23–2.12)	0.539	1.71 (1.25–2.35)
Parent(s) with myocardial infarction	0.258	1.29 (1.13–1.47)	0.402	1.49 (1.25–1.78)
Systolic blood pressure*, mmHg	1.436	4.20 (2.59–6.84)	1.919	6.81 (3.61–12.87)
Body mass index, kg/m^2	0.951	2.59 (1.65–4.05)	0.732	2.08 (1.26–3.44)
Baseline survival function at 10 years
Cohort 1982	0.974		0.996
Cohort 1987	0.977		0.995
Cohort 1992	0.980		0.997
Cohort 1997–2002	0.984		0.996
Layperson oriented
Age*, year	4.219	68.00 (49.20–93.98)	5.739	310.77 (172.55–559.70)
Current smoking	0.642	1.90 (1.68–2.14)	0.929	2.53 (2.04–3.14)
History of diabetes	0.937	2.55 (1.96–3.31)	1.296	3.65 (2.62–5.10)
History of hypertension	0.303	1.35 (1.17–1.57)	0.722	2.06 (1.71–2.47)
Incapable of walking 500 meters	0.462	1.59 (1.21–2.08)	0.491	1.63 (1.19–2.24)
Parent(s) with myocardial infarction,	0.266	1.30 (1.14–1.49)	0.386	1.47 (1.23–1.75)
Body mass index, kg/m^2	1.147	3.15 (2.02–4.91)	0.887	2.43 (1.47–4.02)
Baseline survival function at 10 years
Cohort 1982	0.973		0.996
Cohort 1987	0.977		0.995
Cohort 1992	0.980		0.997
Cohort 1997-2002	0.985		0.996

*Natural logarithm of the continuous variables.