Layperson-Oriented versus Clinical-Based Models for Assessing 10-Year Incidence of Coronary Heart Disease: National FINRISK Study
Table 4
Reclassifications of individuals based on layperson-oriented model as compared with other two models according to 10-year risk categories meaningful for intervention.
Layperson oriented
<5%
5–9%
10–19%
≥20%
Total
NRI ( value)
Men, (%)
Laboratory based
Non-events
0.011 (0.001)
<5%
10292 (93.3)
718 (6.5)
13 (0.1)
0 (0.0)
11023
5–9%
438 (19.6)
1537 (68.6)
264 (11.8)
0 (0.0)
2239
10–19%
6 (0.7)
333 (37.9)
500 (56.9)
40 (4.6)
879
≥20%
0 (0.0)
9 (4.6)
97 (50.0)
88 (45.4)
194
Total
10736
2597
874
128
14335
Events
0.071 (0.004)
<5%
121 (82.9)
24 (16.4)
1 (0.7)
0 (0.0)
146
5–9%
22 (13.9)
117 (74.1)
19 (12.0)
0 (0.0)
158
10–19%
1 (0.8)
43 (33.9)
74 (58.3)
9 (7.1)
127
≥20%
0 (0.0)
2 (4.1)
19 (38.8)
28 (57.1)
49
Total
144
186
113
37
480
Overall NRI
0.081 (0.001)
Non-laboratory based (Layperson oriented + systolic blood pressure)
Non-events
−0.008 (<0.001)
<5%
10450 (97.2)
301 (2.8)
0 (0.0)
0 (0.0)
10751
5–9%
286 (11.5)
2085 (84.0)
110 (4.4)
0 (0.0)
2481
10–19%
0 (0.0)
211 (22.4)
716 (75.9)
16 (1.7)
943
≥20%
0 (0.0)
0 (0.0)
48 (30.0)
112 (70.0)
160
Total
10736
2597
874
128
14335
Events
0.046 (0.018)
<5%
126 (89.4)
15 (10.6)
0 (0.0)
0 (0.0)
141
5–9%
18 (10.2)
145 (82.4)
13 (7.4)
0 (0.0)
176
10–19%
0 (0.0)
26 (21.7)
90 (75.0)
4 (3.3)
120
≥20%
0 (0.0)
0 (0.0)
10 (23.3)
33 (76.7)
43
Total
144
186
113
37
480
Overall NRI
0.038 (0.053)
Women, (%)
Laboratory based
Non-events
0.005 (<0.001)
<5%
15420 (98.3)
262 (1.7)
6 (0.0)
0 (0.0)
15688
5–9%
196 (33.3)
331 (56.3)
60 (10.2)
1 (0.2)
588
10–19%
6 (4.3)
44 (31.4)
76 (54.3)
14 (10.0)
140
≥20%
0 (0.0)
1 (3.1)
13 (40.6)
18 (56.3)
32
Total
15622
638
155
33
16448
Events
0.024 (0.516)
<5%
92 (92.9)
7 (7.1)
0 (0.0)
0 (0.0)
99
5–9%
12 (29.3)
21 (51.2)
7 (17.1)
1 (2.4)
41
10–19%
2 (11.1)
4 (22.2)
10 (55.6)
2 (11.1)
18
≥20%
0 (0.0)
0 (0.0)
3 (27.3)
8 (72.7)
11
Total
106
32
20
11
169
Overall NRI
0.029 (0.432)
Non-laboratory based (Layperson-oriented + systolic blood pressure)