Figure 4: Effects of CNP on Ang II-induced ROS production. (a) Representative photomicrograph of myocardium stained with DHE. (b) DHE fluorescence was quantified to evaluate superoxide levels in situ and expressed relative to values obtained for vehicle-treated with Ang II infusion group (as 100%). (c) NOX4 transcript expression in vehicle- and CNP-treated mice 2 weeks after saline or Ang II infusion. Results are mean ± SEM ( –9 each). * .