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International Journal of Vascular Medicine
Volume 2012, Article ID 654627, 5 pages
http://dx.doi.org/10.1155/2012/654627
Review Article

Interest of Flow Diversion Prostheses in the Management of Unruptured Intracranial Aneurysms

1Pharmacy Department, Groupement Hospitalier Est, Hospices Civils de Lyon, 69500 Bron, France
2Délégation à la Recherche Clinique et à l'Innovation, Cellule Innovation, Hospices Civils de Lyon, avenue Du doyen Lépine, 69500 Bron, France
3UMR-CNRS 5510, Faculté de Pharmacie, Université de Lyon, 69008 Lyon, France
4EA 3452, Faculté de Pharmacie, Université de Nancy, 54001 Nancy, France
5Neuroradiology Departement, Groupement Hospitalier Est, Hospices Civils de Lyon, 69500 Bron, France

Received 28 June 2011; Revised 26 August 2011; Accepted 26 August 2011

Academic Editor: Mark D. Morasch

Copyright © 2012 Xavier Armoiry et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Flow diversion prostheses represent a new endovascular approach aimed at treating patients with large wide-neck aneurysms. Our objective is to present this new technology, to review the clinical studies on efficacy, and to emphasize its current limits. Flow diversion prostheses consist of a cylinder made of a large number of braided microfilaments providing a large metallic surface when deployed and inducing a blood flow diversion outside the aneurysm. Two different brands are currently available. Clinical data supporting their efficacy are currently limited to six non comparative cohort studies that included between 18 and 107 patients. Procedural implantation was shown to be feasible in more than 90% and safe with a thirty-day mortality between 2.8 and 5.5%. Complete occlusion rates at twelve months varied between 85.7 and 100%. Even though promising, the current status of flow diversion prostheses needs further evaluation with randomized, prospective, clinical trials with comparison to conventional strategies including endovascular coiling or surgical clipping.