Review Article

Targeting Endothelial Dysfunction in Vascular Complications Associated with Diabetes

Figure 3

Classic antioxidant pathways for the neutralization of ROS produced by hyperglycaemia in the cytoplasm and mitochondria of endothelial cells. : superoxide anion; : peroxynitrite; : nitrite; H2O2: hydrogen peroxide; : hydroxyl radicals; LOOH: lipid hydroperoxides; LOH: lipid alcohol; Nox: NADPH oxidase.