Targeting Endothelial Dysfunction in Vascular Complications Associated with Diabetes

Table 1

Novel targets that regulate eNOS function.

Compound	Biological action	Disease context	References
BH4	↑co-factor availability	Endothelium-dependent vasodilation, hypercholesterolemia, diabetes	[36–38]
GTPCH	↑BH4 synthesis	Diabetes	[39, 40]
AVE9488	↑eNOS transcription	Atherosclerosis, ischemia-reperfusion injury	[41, 42]
AVE3085	↑eNOS transcription	Atherosclerosis, hypertension	[41, 43]
Fasudil	Stabilise eNOS gene expression, ↑eNOS activity	Atherosclerosis, hypertension, heart failure, diabetes	[44–47]