International Journal of Vascular Medicine / 2012 / Article / Tab 1

Review Article

Targeting Endothelial Dysfunction in Vascular Complications Associated with Diabetes

Table 1

Novel targets that regulate eNOS function.

CompoundBiological actionDisease contextReferences

BH4↑co-factor availabilityEndothelium-dependent vasodilation, hypercholesterolemia, diabetes[3638]
GTPCH↑BH4 synthesisDiabetes[39, 40]
AVE9488↑eNOS transcriptionAtherosclerosis, ischemia-reperfusion injury[41, 42]
AVE3085↑eNOS transcriptionAtherosclerosis, hypertension[41, 43]
FasudilStabilise eNOS gene expression, ↑eNOS activityAtherosclerosis, hypertension, heart failure, diabetes[4447]

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