Elevated Serum C-Reactive Protein and Markers of Sleep Disordered Breathing

Table 3

Association between sleep variables and C-reactive protein levels > 1 mg/dL, by gender.

Sleep summary score	Sample size (hypertension %)	Age-adjusted odds ratio (95% CI)	Multivariable-model 1^∗ odds ratio (95% CI)	Multivariable-model 2^† odds ratio (95% CI)
Men
0	61 (4.30%)	1 (referent)	1 (referent)	1 (referent)
1	90 (5.49%)	1.27 (0.83–1.94)	1.20 (0.79–1.84)	1.12 (0.75–1.66)
2	62 (7.82%)	1.84 (1.14–2.97)	1.71 (1.04–2.81)	1.44 (0.89–2.34)
≥3	17 (7.42%)	1.80 (0.96–3.37)	1.56 (0.84–2.88)	1.24 (0.65–2.35)
P-trend		0.0084	0.0269	0.2038
Women
0	109 (7.44%)	1 (referent)	1 (referent)	1 (referent)
1	144 (11.69%)	1.64 (1.10–2.46)	1.60 (1.07–2.39)	1.15 (0.77–1.72)
2	86 (16.31%)	2.42 (1.66–3.53)	2.29 (1.56–3.36)	1.49 (0.96–2.31)
≥3	36 (20.96%)	3.30 (2.10–5.17)	3.03 (1.91–4.80)	1.50 (1.02–2.21)
P-trend		<0.0001	<0.0001	0.0487

*Model 1: adjusted for age (years), race/ethnicity (non-Hispanic whites, non-Hispanic blacks, and Mexican Americans, others), education (below high school, high school, and above high school), smoking (never smoker, former smoker, and current smoker), and alcohol intake (absent, present).
^†Model 2: adjusted for age (years), race/ethnicity (non-Hispanic whites, non-Hispanic blacks, and Mexican Americans, others), education (below high school, high school, above high school), smoking (never smoker, former smoker, current smoker), alcohol intake (absent, present), physical activity (moderate physical activity), body mass index (obese, nonobese), depression (absent, present), diabetes (absent, present), and total cholesterol (mg/dL).