The Oxidative State of Chylomicron Remnants Influences Their Modulation of Human Monocyte Activation
MCP-1 production by human primary blood monocytes after incubation with native, oxidised, or probucol-treated CRLPs. Monocytes were incubated with CRLPs, oxCRLPs or pCRLPs (a) 15 μg/mL cholesterol; (b) 30 μg/mL cholesterol) for 24 h at 37°C. After this time cells were pelleted and the supernatants were collected for analysis by ELISA. monocyte isolations. * compared to control, # compared to pCRLPs-treated monocytes. One-way ANOVA with Bonferroni’s posttest.
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