The Oxidative State of Chylomicron Remnants Influences Their Modulation of Human Monocyte Activation

Figure 3

MCP-1 production by human primary blood monocytes after incubation with native, oxidised, or probucol-treated CRLPs. Monocytes were incubated with CRLPs, oxCRLPs or pCRLPs (a) 15 μg/mL cholesterol; (b) 30 μg/mL cholesterol) for 24 h at 37°C. After this time cells were pelleted and the supernatants were collected for analysis by ELISA. 𝑛=3 monocyte isolations. *𝑃<0.05 compared to control, ^#𝑃<0.05 compared to pCRLPs-treated monocytes. One-way ANOVA with Bonferroni’s posttest.

(a)

(b)