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International Journal of Vascular Medicine
Volume 2012, Article ID 949672, 3 pages
Review Article

The Role of Bile Acid Excretion in Atherosclerotic Coronary Artery Disease

Department of Internal Medicine “C”, Tel Aviv Sourasky Medical Center, Tel Aviv 64239, Israel

Received 30 May 2011; Accepted 14 July 2011

Academic Editor: John C. L. Mamo

Copyright © 2012 Gideon Charach et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The impact of cholesterol and different classes of lipoproteins on the development of coronary artery disease (CAD) has been investigated in extensively during the past 50 years. The cholesterol metabolism is dependent on numerous factors, including dietary fat, fractional absorption of dietary cholesterol, tissue stores of cholesterol, endogenous cholesterol synthesis, and fecal bile excretion. Several studies showed significantly lower amounts of bile acid secretion in adult patients with CAD compared to non-CAD patients. Could it be that the inability to efficiently excrete bile acids may lead to CAD development?