International Journal of Vascular Medicine / 2013 / Article / Tab 2

Review Article

Aortic Disease in the Young: Genetic Aneurysm Syndromes, Connective Tissue Disorders, and Familial Aortic Aneurysms and Dissections

Table 2

Major Ghent criteria used to diagnose Marfan syndrome.

SystemMajor criteria

Skeletal system Pectus carinatum
Pectus excavatum requiring surgery
Upper to lower segment ratio <0.86 or span to height ratio >1.05
Arachnodactyly: wrist and thumb signs
Pes planus
Protrusio acetabuli
Scoliosis > 20 d or spondylolisthesis
Reduced extensions at the elbows (<170 d)

Ocular systemEctopia lentis (dislocated lens)

Cardiovascular system Dilatation of the ascending aorta
Aortic root dilatation

Dura Lumbosacral dural ectasia

Family/genetic history Family history
Genetic mutations known to cause Marfan syndrome
Inheritance of DNA maker haplotype linked to MFS in the family

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