Vascular Reactivity Concerning Orthosiphon stamineus Benth-Mediated Antihypertensive in Aortic Rings of Spontaneously Hypertensive Rats

Table 2

Maximal relaxant effects (𝑅_max) and sensitivity (pD₂) for ACh-induced relaxation in aortic rings in the absence and presence of indomethacin and L-NAME.

Treatment groups	ACh		ACh + indomethacin		ACh + L-NAME
	𝑅max (% of relaxation)	pD2 (−log EC50)	𝑅max (% of relaxation)	pD2 (−log EC50)	𝑅max (% of relaxation)	pD2 (−log EC50)
Control	73.15±3.03	7.72±0.15	91.74±2.39	7.33±0.08	NI	NI
Losartan (10 mg/kg)	111.20±4.08^#	7.98±0.17	90.20±𝟕.64^∗	7.31±0.28	29.55±2.46^∗	6.73±0.30
WOS; (1000 mg/kg)	76.42±3.39	7.62±0.17	91.04±3.07	7.26±0.11	7.12±1.35^∗	8.17±0.88
WMOS (1000 mg/kg)	79.56±2.97	7.24±0.12	96.37±6.33^∗	7.32±0.24	NI	NI

Values are mean ± SEM of 5 to 8 SHRs in each group. ^#Denotes 𝑃<0.05 compared to control and *denotes 𝑃<0.05 compared to ACh without inhibitors. NI: not identified by nonlinear regression analysis by GraphPad Prism 5.0.