International Journal of Vascular Medicine

Review Article

Association between Thrombophilia and the Post-Thrombotic Syndrome

Table 2

Included studies in chronic venous ulcer patients.
ReferenceAuthor/yearNumber of patients includedCriteria for PTS diagnosis (%) with PTS Number with thrombophiliaAssociation between thrombophilia and PTS
[35] Zutt et al., 2011 310 Duplex Doppler ultrasound and/or venography 142 (45.8)59 FVLPTS positive 42/127, PTS negative 17/128,
57 APC resPTS positive 40/127, PTS negative 17/128,
8 PTMPTS positive 5/125, PTS negative 3/161,
2 LACPTS positive 2/120, PTS negative 0/144,
75 APLACL-PTS positive 15/112, PTS negative 29/124,  
Ab2GI-PTS positive 17/110, PTS negative 14/114,
22 PCPTS positive 15/105, PTS negative 7/112,
35 PSPTS positive 23/95, PTS negative 12/108,
34 ATPTS positive 16/139, PTS negative 18/160,
[36]Hafner et al., 200173Duplex Doppler ultrasound and history of DVT42 (58)21 FVLPTS positive 16/42, PTS negative 5/31, OR 3.2 95% CI 1–10,
[37]Wiszniewski et al., 2011110Duplex Doppler ultrasound and history of DVT64 (58.2)20 FVL
2 PTM
8 PS
7 PC
3 AT
5 LAC
12 ACL		1/3 of patients with CVU have ≥1 thrombophilia
All patients with thrombophilia experienced ≥1 previous DVT
In 94% of patients with CVU and thrombophilia, DVT was recurrent, and in 88% of them, both recurrent DVT and recurrent CVU were observed
CVU persisted longer compared to patients with CVU and no thrombophilia
[38]Maessen-Visch et al., 199992Light reflex rheography and history of DVT 53 (57.6)21 FVLPTS positive 19/53, PTS negative 2/39,
[39]Gaber et al., 2001100Duplex Doppler ultrasound, light reflex rheography or phlebography53 (53)22 APC resPTS positive 19/53, PTS negative 3/47, OR 8.2 95% CI 2.55–26.33
[40] MacKenzie et al., 2002 88 Duplex Doppler ultrasound and/or history of DVT 22 (25)3 FVLPTS positive 2/22, PTS negative 1/66, = NS
14 APC resPTS positive 5/22, PTS negative 9/66, = NS
11 PTMPTS positive 3/22, PTS negative 8/66, = NS
6 PSPTS positive 2/22, PTS negative 4/66, = NS
5 PCPTS positive 2/22, PTS negative 3/66, = NS
4 ATPTS positive 3/22, PTS negative 1/66,
8 LACPTS positive 1/22, PTS negative 7/66, = NS
12 ACLPTS positive 6/22, PTS negative 6/66,
[41] Ribeaudeau et al., 1999 35 Duplex Doppler ultrasound and/or history of DVT 14 (40)1 FVL PTS positive 1/10, PTS negative 0/20
4 APC resPTS positive 1/14, PTS negative 3/21
2 PTMPTS positive 1/10, PTS negative 1/20
3 APLPTS positive 1/12, PTS negative 2/18
FVL: factor V Leiden, PTM: prothrombin G20210A, APC res: activated protein C resistance, LAC: lupus anticoagulant, APL: antiphospholipid antibodies, ACL: Anticardiolipin antibodies, PC: protein C deficiency, PS: protein S deficiency, AT: antithrombin deficiency, FVIII: coagulation factor VIII, DVT: deep vein thrombosis, CVU: chronic venous ulcer, PTS: post thrombotic syndrome, OR: odds ratio, CI: confidence interval, and NS: nonsignificant.