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International Journal of Vascular Medicine
Volume 2013 (2013), Article ID 857019, 5 pages
http://dx.doi.org/10.1155/2013/857019
Research Article

Epicardial Coronary Arteries in Khat Chewers Presenting with Myocardial Infarction

1Department of Cardiology, Faculty of Medicine, Sana’a University, Sana’a 13078, Yemen
2Department of Cardiology, Heart Hospital, Hamad Medical Corporation, 3050 Doha, Qatar
3Department of Cardiology, Faculty of Medicine, Ain Shams University, Cairo 11361, Egypt
4Clinical Medicine, Weill Cornell Medical College, 24144 Doha, Qatar
5Cardiology Unit, Internal Medicine, Ahmed Maher Teaching Hospital, Cairo, Egypt
6Clinical Research, Trauma Surgery Section, Hamad Medical Corporation, 3050 Doha, Qatar

Received 25 June 2013; Accepted 29 August 2013

Academic Editor: Karl A. Illig

Copyright © 2013 Ahmed Al-Motarreb et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. Khat chewing is a common habit in Yemen despite increased evidence of its negative impact on the cardiovascular system. Aims. We aimed to study the epicardial coronary arteries in khat chewers presenting with myocardial infarction (AMI). Materials and Methods. A descriptive, cross-sectional study was conducted between November 2008 and May 2009 in Yemen. AMI patients who underwent coronary angiogram were enrolled and divided into groups (gp): gp1 (diabetic and khat chewers), gp2 (khat chewers and nondiabetic), and gp3 (diabetic and non-khat users). Results. Of 347 AMI patients 63%, 21%, and 16% were in gp 2, 3, and 1, respectively. Khat chewers were younger in comparison to non-khat users. Group 3 patients were more likely to have multivessel disease, severe left anterior descending (LAD), right coronary artery (RCA) stenosis and total RCA, and left circumflex (Lcx) occlusion compared to other groups. Group 1 patients were more likely to have total LAD occlusion and severe Lcx lesions. In multivariate analysis, age, diabetes mellitus, and smoking were significant independent predictors for significant coronary artery lesions; however, khat chewing did not show such association. Conclusions. Coronary spasm is the main mechanism of AMI in khat chewers. The impact of our finding for risk stratification and management warrants further studies.