Clinical Study
Greater Endothelial Apoptosis and Oxidative Stress in Patients with Peripheral Artery Disease
Table 3
Circulating inflammatory, antioxidant capacity, and vascular biomarkers of subjects with peripheral artery disease (PAD) and controls.
| Variables
| Control group | PAD group | value |
| | C-reactive protein (mg/L) | 0.80 (1.20) | 4.10 (5.96) | <0.001 | | Tissue necrosis factor alpha (pg/mL) | 46 (18) | 52 (26) | 0.414 | | Interleukin-1b (pg/mL) | 19 (7) | 16 (5) | 0.036 | | Interleukin-6 (pg/mL) | 21 (12) | 24 (12) | 0.539 | | Interleukin-8 (pg/mL) | 58 (26) | 96 (56) | <0.001 | | Monocyte chemotactic protein-1 (pg/mL) | 1102 (1135) | 1146 (1712) | 0.489 | | Myeloperoxidase (pg/mL) | 525 (1285) | 28 (39) | 0.145 | | Matrix metallopeptidase-9 (pg/mL) | 1035 (1189) | 685 (311) | 0.398 | | Serum amyloid A (pg/mL) | 5563 (2253) | 9335 (3818) | <0.001 | | Hydroxyl Radical Antioxidant Capacity (arbitrary units) | 1.91 (0.77) | 0.95 (0.24) | <0.001 | | E selectin (pg/mL) | 49 (63) | 40 (49) | 0.412 | | Vascular cell adhesion molecule-1 (pg/mL) | 1010 (568) | 2164 (876) | <0.001 | | Intercellular cell adhesion molecule-1 (pg/mL) | 1874 (2704) | 1936 (1294) | 0.763 | | Vascular endothelial growth factor-A (pg/mL) | 52 (114) | 29 (34) | <0.001 | | Leptin (pg/mL) | 721 (3068) | 1974 (3032) | 0.214 | | Adiponectin (pg/mL) | 3450 (653) | 5540 (1501) | <0.001 | | Plasminogen activator inhibitor-1 (ng/mL) | 497 (1084) | 726 (468) | 0.595 | | Apolipoprotein B (ng/mL) | 23 (63) | 66 (57) | 0.013 | | Apolipoprotein CIII (ng/mL) | 928 (822) | 1336 (906) | 0.035 | | Hepatocyte growth factor (pg/mL) | 126 (103) | 71 (38) | <0.001 | | Nerve growth factor (pg/mL) | 12 (3) | 14 (8) | 0.060 |
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Values are medians (interquartile ranges).
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