Purpurogallin, a Natural Phenol, Attenuates High-Mobility Group Box 1 in Subarachnoid Hemorrhage Induced Vasospasm in a Rat Model

Figure 3

High-mobility group protein B1 (HMGB1) expression on 24 hr after first SAH and 72 hr after second SAH, respectively (Western blot). (A) SAH; (B) SAH + vehicle; (C) 100 ug/kg/day purpurogallin + SAH; (D) 200 ug/kg/day purpurogallin + SAH; and (E) 400 ug/kg/day purpurogallin in SAH rats. Purpurogallin tended to decrease HMGB1 expression in 48 hr after the induction of SAH. By the end of second SAH, purpurogallin dose-dependently attenuated HMGB1 protein expression. , experimental animals compared with the SAH group. , compared with the animals subject to SAH.