Occipital Artery Function during the Development of 2-Kidney, 1-Clip Hypertension in Rats

Table 2

Contractile effects of agonists on proximal and distal segments of the occipital artery.

Agonist	Parameter	Proximal segments		Distal segments
		SHAM	2K-1C	SHAM	2K-1C
Angiotensin II	EC50, nM	6.5 ± 1.3	6.8 ± 1.5	4.1 ± 1.4	3.0 ± 1.6
	𝐸max, %𝑇𝐾	66.8 ± 10.1	18.5 ± 3.8*	44.9 ± 7.8	14.0 ± 2.9*
AVP	EC50, nM	2.5 ± 1.3	2.2 ± 1.5	1.5 ± 1.5	1.2 ± 1.5
	𝐸max, %𝑇𝐾	28.8 ± 4.0	25.7 ± 5.0	79.2 ± 7.3^†	72.3 ± 8.6^†
5-HT	EC50, nM	1,941 ± 119	2,852 ± 120*	844 ± 110^†	941 ± 113^†
	𝐸max, %𝑇𝐾	113.3 ± 6.5	100.3 ± 6.2	121.3 ± 2.8	112.2 ± 6.2

Data are presented as mean ± SEM. AVP: arginine vasopressin. 5-HT: 5-hydroxytryptamine. EC₅₀: concentration causing 50% maximal contraction. 𝐸_max %𝑇_𝐾: maximal contraction as a percentage of the response elicited by 80 mM K⁺. There were 8 artery segments in each group. ^∗𝑃 < 0.05 in 2K-1C versus SHAM; ^†𝑃 < 0.05 in distal versus proximal segments.