Occipital Artery Function during the Development of 2-Kidney, 1-Clip Hypertension in Rats

Table 3

Contractile effects of angiotensin II, AVP, and 5-HT receptor agonists in common carotid arteries from 2K-1C and SHAM rats.

Constrictor	EC50, nM		𝐸max, %𝑇𝐾
	SHAM	2K-1C	SHAM	2K-1C
Angiotensin II	7.9 ± 1.2	7.0 ± 1.2	73.6 ± 18.9	13.1 ± 3.9*
AVP	2.8 ± 1.5	10.2 ± 1.9*	7.4 ± 3.5	3.5 ± 1.1
5-HT	3,246 ± 144	2,204 ± 121*	98.8 ± 26.7	121.0 ± 21.4

Data are presented as mean ± SEM. AVP: arginine vasopressin. 5-HT: 5-hydroxytryptamine. EC₅₀: concentration causing 50% maximal contraction. 𝐸_max, %𝑇_𝐾: maximal contraction as a percentage of the response elicited by 80 mM K⁺. There were 6 artery segments in each group. ^∗𝑃 < 0.05 in 2K-1C versus SHAM.