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International Journal of Vascular Medicine
Volume 2014, Article ID 859726, 5 pages
http://dx.doi.org/10.1155/2014/859726
Review Article

Influence of Acquired and Genetic Risk Factors on the Prevention, Management, and Treatment of Thromboembolic Disease

Department of Vascular Surgery, Saint George Hospital, University Medical Center, University of Balamand, Youssef Sursock Street, P.O. Box 166378, Achrafieh, Beirut 1100 2807, Lebanon

Received 22 December 2013; Accepted 11 June 2014; Published 26 June 2014

Academic Editor: Robert M. Schainfeld

Copyright © 2014 Raghid Kreidy. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Prevention, management, and treatment of venous thromboembolism requires understanding of the epidemiology and associated risk factors, particularly in recognizing populations warranting prophylaxis, in evaluating patients with high risk situations, and in determining the duration of anticoagulation required to minimize recurrent thrombosis and to avoid postthrombotic syndrome. The present paper reviews recent advances concerning acquired and genetic risk factors for venous thrombosis, analyses individual risks related to age, and focuses on thrombotic genetic risk factors and the synergistic gene-environment and gene-gene interactions and their importance in the management and treatment of venous thromboembolic disease.