Investigation of TGFβ1-Induced Long Noncoding RNAs in Endothelial Cells

Table 4

Results of bioinformatics GO (gene ontology) enrichment analyses to determine the roles of differentially expressed mRNAs in GO terms.

	Upregulated				Downregulated
	GO term	Count	% of total DE genes	value	GO term	Count	% of total DE genes	value
Biological process	Cell communication	686	41.7		Response to stimulus	587	55.3
	Biological regulation	1136	69.1		Cation transport	97	9.1
	Organ development	356	21.7		Multicellular organismal process	494	46.6
	Anatomical structure development	540	32.8		Single-multicellular organism process	478	45.1
	Signaling	674	41.0		Cell surface receptor signaling pathway	265	25.0
Cellular component	Plasma membrane part	273	15.5		Plasma membrane	380	33.9
	Neuron part	123	7.0		Cell periphery	386	34.5
	Intrinsic component of plasma membrane	170	9.7		Cell part	1006	89.8
	Cell projection	180	10.2		Cell	1006	89.8
	Cell periphery	525	29.9		Integral component of membrane	389	34.7
Molecular function	Channel activity	68	4.2		Signaling receptor activity	124	12.0
	Passive transmembrane transporter activity	68	4.2		Receptor activity	138	13.3
	Transmembrane transporter activity	124	7.7		Signal transducer activity	144	13.9
	Protein binding	917	57.1		Molecular transducer activity	144	13.9
	Cation transmembrane transporter activity	85	5.3		Transmembrane signaling receptor activity	113	10.9