Table of Contents Author Guidelines Submit a Manuscript
International Journal of Vascular Medicine
Volume 2017, Article ID 2390174, 7 pages
https://doi.org/10.1155/2017/2390174
Research Article

Circulating Angiogenic Growth Factors in Diabetes Patients with Peripheral Arterial Disease and Exertional Leg Pain in Ghana

1Department of Physiology, School of Biomedical & Allied Health Sciences, University of Ghana, Accra, Ghana
2Department of Medical Laboratory Sciences, School of Biomedical & Allied Health Sciences, University of Ghana, Accra, Ghana
3Department of Immunology, Noguchi Memorial Institute for Medical Research, University of Ghana, Accra, Ghana
4Department of Chemical Pathology, School of Biomedical & Allied Health Sciences, University of Ghana, Accra, Ghana
5Department of Medicine & Therapeutics, School of Medicine & Dentistry, University of Ghana, Accra, Ghana

Correspondence should be addressed to Kwame Yeboah; moc.liamg@yknivlem

Received 23 August 2017; Revised 27 November 2017; Accepted 29 November 2017; Published 27 December 2017

Academic Editor: Robert M. Schainfeld

Copyright © 2017 Kwame Yeboah et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. F. G. R. Fowkes, D. Rudan, I. Rudan et al., “Comparison of global estimates of prevalence and risk factors for peripheral artery disease in 2000 and 2010: a systematic review and analysis,” The Lancet, vol. 382, no. 9901, pp. 1329–1440, 2013. View at Publisher · View at Google Scholar · View at Scopus
  2. K. Yeboah, P. Puplampu, E. Yorke, D. A. Antwi, B. Gyan, and A. G. B. Amoah, “Body composition and ankle-brachial index in Ghanaians with asymptomatic peripheral arterial disease in a tertiary hospital,” BMC Obesity, vol. 3, no. 1, pp. 1–7, 2016. View at Publisher · View at Google Scholar
  3. N. A. Khan, S. A. Rahim, S. S. Anand, D. L. Simel, and A. Panju, “Does the clinical examination predict lower extremity peripheral arterial disease?” Journal of the American Medical Association, vol. 295, no. 5, pp. 536–546, 2006. View at Publisher · View at Google Scholar · View at Scopus
  4. G. C. Lend and F. G. R. Fowkes, “The Edinburgh claudication questionnaire: an improved version of the WHO/Rose Questionnaire for use in epidemiological surveys,” Journal of Clinical Epidemiology, vol. 45, no. 10, pp. 1101–1109, 1992. View at Publisher · View at Google Scholar · View at Scopus
  5. L. Potier, C. Abi Khalil, K. Mohammedi, and R. Roussel, “Use and utility of Ankle brachial index in patients with diabetes,” European Journal of Vascular and Endovascular Surgery, vol. 41, no. 1, pp. 110–116, 2011. View at Publisher · View at Google Scholar · View at Scopus
  6. A. Banerjee, F. G. Fowkes, and P. M. Rothwell, “Associations between peripheral artery disease and ischemic stroke: implications for primary and secondary prevention,” Stroke, vol. 41, no. 9, pp. 2102–2107, 2010. View at Publisher · View at Google Scholar · View at Scopus
  7. G. Y. Koh, “Orchestral actions of angiopoietin-1 in vascular regeneration,” Trends in Molecular Medicine, vol. 19, no. 1, pp. 31–39, 2013. View at Publisher · View at Google Scholar · View at Scopus
  8. E. Fagiani and G. Christofori, “Angiopoietins in angiogenesis,” Cancer Letters, vol. 328, no. 1, pp. 18–26, 2013. View at Publisher · View at Google Scholar · View at Scopus
  9. World Health Organization, “Waist circumference and waist-hip ratio: Report of a WHO expert consultation,” Tech. Rep., WHO, Geneva, Switzerland, 2011. View at Google Scholar
  10. A. T. Hirsch, M. H. Criqui, D. Treat-Jacobson et al., “Peripheral arterial disease detection, awareness, and treatment in primary care,” The Journal of the American Medical Association, vol. 286, no. 11, pp. 1317–1324, 2001. View at Publisher · View at Google Scholar · View at Scopus
  11. A. D. Blann, F. M. Belgore, C. N. McCollum, S. Silverman, P. L. Lip, and G. Y. H. Lip, “Vascular endothelial growth factor and its receptor, Flt-I, in the plasma of patients with coronary or peripheral atherosclerosis, or type II diabetes,” Clinical Science, vol. 102, no. 2, pp. 187–194, 2002. View at Publisher · View at Google Scholar · View at Scopus
  12. A. J. Makin, N. A. Y. Chung, S. H. Silverman, and G. Y. H. Lip, “Vascular endothelial growth factor and tissue factor in patients with established peripheral artery disease: A link between angiogenesis and thrombogenesis?” Clinical Science, vol. 104, no. 4, pp. 397–404, 2003. View at Publisher · View at Google Scholar · View at Scopus
  13. C. M. Findley, R. G. Mitchell, B. D. Duscha, B. H. Annex, and C. D. Kontos, “Plasma levels of soluble Tie2 and vascular endothelial growth factor distinguish critical limb ischemia from intermittent claudication in patients with peripheral arterial disease,” Journal of the American College of Cardiology, vol. 52, no. 5, pp. 387–393, 2008. View at Publisher · View at Google Scholar · View at Scopus
  14. K. Yeboah, P. Puplampu, J. Ainuson, J. Akpalu, B. Gyan, and A. G. B. Amoah, “Peripheral artery disease and exertional leg symptoms in diabetes patients in Ghana,” BMC Cardiovascular Disorders, vol. 16, no. 1, article 68, 2016. View at Publisher · View at Google Scholar
  15. P. Vempati, A. S. Popel, and F. Mac Gabhann, “Extracellular regulation of VEGF: Isoforms, proteolysis, and vascular patterning,” Cytokine & Growth Factor Reviews, vol. 25, no. 1, pp. 1–19, 2014. View at Publisher · View at Google Scholar · View at Scopus
  16. R. Kikuchi, K. Nakamura, S. MacLauchlan et al., “An antiangiogenic isoform of VEGF-A contributes to impaired vascularization in peripheral artery disease,” Nature Medicine, vol. 20, no. 12, pp. 1464–1471, 2014. View at Publisher · View at Google Scholar · View at Scopus
  17. H. S. Lim, A. D. Blann, A. Y. Chong, B. Freestone, and G. Y. Lip, “Plasma vascular endothelial growth factor, angiopoietin-1, and angiopoietin-2 in diabetes: implications for cardiovascular risk and effects of multifactorial intervention,” Diabetes Care, vol. 27, no. 12, pp. 2918–2924, 2004. View at Publisher · View at Google Scholar · View at Scopus
  18. S. Nomura, A. Shouzu, S. Omoto et al., “Effects of eicosapentaenoic acid on endothelial cell-derived microparticles, angiopoietins and adiponectin in patients with type 2 diabetes,” Journal of Atherosclerosis and Thrombosis, vol. 16, no. 2, pp. 83–90, 2009. View at Publisher · View at Google Scholar · View at Scopus
  19. S. Anuradha, V. Mohan, K. Gokulakrishnan, and M. Dixit, “Angiopoietin-2 levels in glucose intolerance, hypertension, and metabolic syndrome in Asian Indians (Chennai Urban Rural Epidemiology Study-74),” Metabolism - Clinical and Experimental, vol. 59, no. 6, pp. 774–779, 2010. View at Publisher · View at Google Scholar · View at Scopus
  20. S. K. Nadar, A. Blann, D. G. Beevers, and G. Y. H. Lip, “Abnormal angiopoietins 1&2, angiopoietin receptor Tie-2 and vascular endothelial growth factor levels in hypertension: Relationship to target organ damage [a sub-study of the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT)],” Journal of Internal Medicine, vol. 258, no. 4, pp. 336–343, 2005. View at Publisher · View at Google Scholar · View at Scopus
  21. Y. Reiss, A. Scholz, and K. H. Plate, “The angiopoietin—tie system: common signaling pathways for angiogenesis, cancer, and inflammation,” in Endothelial Signaling in Development and Disease, pp. 313–328, Springer, 2015. View at Google Scholar
  22. B. Hoier, M. Walker, M. Passos et al., “Angiogenic response to passive movement and active exercise in individuals with peripheral arterial disease,” Journal of Applied Physiology, vol. 115, no. 12, pp. 1777–1787, 2013. View at Publisher · View at Google Scholar · View at Scopus
  23. C. D. Askew, S. Green, P. J. Walker et al., “Skeletal muscle phenotype is associated with exercise tolerance in patients with peripheral arterial disease,” Journal of Vascular Surgery, vol. 41, no. 5, pp. 802–807, 2005. View at Publisher · View at Google Scholar · View at Scopus
  24. J. L. Robbins, W. Schuyler Jones, B. D. Duscha et al., “Relationship between leg muscle capillary density and peak hyperemic blood flow with endurance capacity in peripheral artery disease,” Journal of Applied Physiology, vol. 111, no. 1, pp. 81–86, 2011. View at Publisher · View at Google Scholar · View at Scopus
  25. A. V. Benest, A. H. Salmon, W. Wang et al., “VEGF and angiopoietin-1 stimulate different angiogenic phenotypes that combine to enhance functional neovascularization in adult tissue,” Microcirculation, vol. 13, no. 6, pp. 423–437, 2006. View at Publisher · View at Google Scholar · View at Scopus
  26. D. Qin, T. Trenkwalder, S. Lee et al., “Early vessel destabilization mediated by angiopoietin-2 and subsequent vessel maturation via angiopoietin-1 induce functional neovasculature after ischemia,” PLoS ONE, vol. 8, no. 4, article e61831, 2013. View at Publisher · View at Google Scholar · View at Scopus
  27. P. C. Bennett, P. S. Gill, S. Silverman, A. D. Blann, B. Balakrishnan, and G. Y. H. Lip, “Ethnic/racial differences in circulating markers of angiogenesis and their association with cardiovascular risk factors and cardiovascular disease,” International Journal of Cardiology, vol. 167, no. 4, pp. 1247–1250, 2013. View at Publisher · View at Google Scholar · View at Scopus
  28. J. A. Beckman, C. O. Higgins, and M. Gerhard-Herman, “Automated oscillometric determination of the ankle-brachial index provides accuracy necessary for office practice,” Hypertension, vol. 47, no. 1, pp. 35–38, 2006. View at Publisher · View at Google Scholar · View at Scopus
  29. W. J. Verberk, A. Kollias, and G. S. Stergiou, “Automated oscillometric determination of the ankle-brachial index: A systematic review and meta-analysis,” Hypertension Research, vol. 35, no. 9, pp. 883–891, 2012. View at Publisher · View at Google Scholar · View at Scopus