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International Journal of Vascular Medicine
Volume 2018, Article ID 6428630, 7 pages
Research Article

Effect of N-Acetylcysteine on Dyslipidemia and Carbohydrate Metabolism in STZ-Induced Diabetic Rats

Department of Chemistry and Biochemistry, Institute of Biosciences of Botucatu, Sao Paulo State University (UNESP), Rua Professor Doutor Antônio Celso Wagner Zanin s/n, Distrito de Rubião Júnior, 18618-689 Botucatu, SP, Brazil

Correspondence should be addressed to Ana Angélica Henrique Fernandes; rb.psenu.bbi@acilegna

Received 12 July 2017; Accepted 27 December 2017; Published 28 January 2018

Academic Editor: Bhagwan Satiani

Copyright © 2018 Anderson Kiyoshi Kaga et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Type 1 diabetes mellitus (T1DM) is characterized by insulin-deficient production leading to hyperglycemia, which is associated with diabetic complications such as cardiovascular diseases. Antioxidants have been proving a good alternative to diabetic complications, with N-acetylcysteine (NAC) having antioxidant characteristics. The aim of this study was to assess the effect of NAC on the lipid profile and the atherogenic index (AI) in streptozotocin- (STZ-) induced diabetic rats. Method. 32 male Wistar rats (60 days of age) weighting ±250 g were randomly distributed into four groups (): CTRL: control rats; CTRL+NAC: control rats treated with NAC; DM: diabetic rats; DM+NAC: diabetic rats treated with NAC. T1DM was induced using STZ (60 mg/kg, ip; single dose), and NAC (25 mg/kg/day) was administrated by gavage, for 37 days. The animals received chow and water ad libitum. After the experimental period, blood and cardiac tissue samples were collected to analyze energetic metabolism, lipid profile, and AI. Results. NAC decreased () glycemia, energy intake, carbohydrate, and protein consumption in diabetic rats (DM+NAC), when compared with DM, while the alimentary efficiency was improved () in treated diabetic rats (DM+NAC). Diabetic rats treated with NAC decreased () lipid profile and AI in diabetic rats (DM+NAC) when compared to DM. Conclusion. NAC improves lipid profile and decreases AI in STZ-induced diabetic rats.