Is Nonmicronized Diosmin 600 mg as Effective as Micronized Diosmin 900 mg plus Hesperidin 100 mg on Chronic Venous Disease Symptoms? Results of a Noninferiority Study

Table 2

Clinical efficacy of diosmin 600 mg once daily (D-group) compared to diosmin 900 mg plus hesperidin 100 mg once daily (D/H-group) in noninferiority analysis (per-protocol population).

	D-group	D/H-group
Venous symptoms (VAS) (mm)
Baseline	47.1 (8.2)	50.3 (9.5)
Endpoint	23.3 (8.6)	26.4 (11.7)
Change endpoint-baseline	-23.8 (10.8)	-23.9 (12.6)
Percentage of variation	-49.6 (19.4)	-47.0 (23.0)
Adjusted means of the changes (least square means)
Estimate-adjusted mean (SE) baseline	-24.9 (1.3)	-22.8 (1.3)
-value	-18.7	-17.1
	<0.0001	<0.0001
90% CI	-27.1; -22.7	-25.0; -20.6
Difference (least square means)
Estimate difference (SE)	-2.1 (1.9)
-value	-1.12
	0.2648
90% CI	-5.3; 1.0

Pr: probability; SE: standard error; VAS: visual analog scale.