International Journal of Vascular Medicine / 2020 / Article / Tab 2

Clinical Study

Is Nonmicronized Diosmin 600 mg as Effective as Micronized Diosmin 900 mg plus Hesperidin 100 mg on Chronic Venous Disease Symptoms? Results of a Noninferiority Study

Table 2

Clinical efficacy of diosmin 600 mg once daily (D-group) compared to diosmin 900 mg plus hesperidin 100 mg once daily (D/H-group) in noninferiority analysis (per-protocol population).


Venous symptoms (VAS) (mm)
 Baseline47.1 (8.2)50.3 (9.5)
 Endpoint23.3 (8.6)26.4 (11.7)
 Change endpoint-baseline-23.8 (10.8)-23.9 (12.6)
 Percentage of variation-49.6 (19.4)-47.0 (23.0)
Adjusted means of the changes (least square means)
 Estimate-adjusted mean (SE) baseline-24.9 (1.3)-22.8 (1.3)
 90% CI-27.1; -22.7-25.0; -20.6
Difference (least square means)
 Estimate difference (SE)-2.1 (1.9)
 90% CI-5.3; 1.0

Pr: probability; SE: standard error; VAS: visual analog scale.

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