Segmental Arterial Mediolysis: A Multiguised Vasospastic Arteriopathy with Collateral Mesangial Cell Hyperplasia and Cardiac Toxicity Generated by Norepinephrine and Hyperdense Adrenoceptors Alone or by Crosstalk with Other Pressor Agents

Figure 12

Segmental arterial mediolysis injurious phase. The black arrow points to an arterial gap lined by a linear adventitial fibrin deposit. The adjacent arterial wall at the red arrow shows total medial replacement with granulation tissue consisting of a few dilated capillaries in expanded extracellular matrix material. The internal elastica here is preserved. Movat stain ×50 (adapted with permission from the American Journal of Surgical Pathology 13(7) copyright l989, Lippincott, Williams and Williams).