Segmental Arterial Mediolysis: A Multiguised Vasospastic Arteriopathy with Collateral Mesangial Cell Hyperplasia and Cardiac Toxicity Generated by Norepinephrine and Hyperdense Adrenoceptors Alone or by Crosstalk with Other Pressor Agents

Figure 19

Segmental arterial mediolysis reparative phase. The renal artery lumen identified by the internal elastica at the red arrow is severely compressed by a circumferential proliferation of granulation tissue replacing the outer 2/3 of the media (white star) and the lower and left mid adventitial tissue (blue star). The white arrow points to the external elastica (black membrane), and the red arrows point to the adventitial tissue. Movat stain ×100 (ad4pted with permission from Veterinary Pathology 52(6), copyright 2015, Sage Publications Inc.).