Segmental Arterial Mediolysis: A Multiguised Vasospastic Arteriopathy with Collateral Mesangial Cell Hyperplasia and Cardiac Toxicity Generated by Norepinephrine and Hyperdense Adrenoceptors Alone or by Crosstalk with Other Pressor Agents

<div>Glomeruli in segmental arterial mediolysis. The glomerulus in (a) exhibits an in tandem arrangement of hyperplastic mesangial cells in the glomerular stalks. Glomerulus in (b) in addition to mesangial hyperplasia also shows at the red arrow a segmental aggregation of matrix material obscuring the adjacent glomerular loop. Hematoxylin &amp; eosin ×400 (adapted with permission from Laboratory Investigation 35(1) copyright 1976, Nature Publishing Group).</div>

International Journal of Vascular Medicine

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Figure 35

Figure 35: Segmental Arterial Mediolysis: A Multiguised Vasospastic Arteriopathy with Collateral Mesangial Cell Hyperplasia and Cardiac Toxicity Generated by Norepinephrine and Hyperdense Adrenoceptors Alone or by Crosstalk with Other Pressor Agents 

Figure 35 | Segmental Arterial Mediolysis: A Multiguised Vasospastic Arteriopathy with Collateral Mesangial Cell Hyperplasia and Cardiac Toxicity Generated by Norepinephrine and Hyperdense Adrenoceptors Alone or by Crosstalk with Other Pressor Agents 