Renal Vascular Response to Angiotensin II Administration in Two Kidneys-One Clip Hypertensive Rats Treated with High Dose of Estradiol: The Role of Mas Receptor

Table 1

Baseline data for SBP (mmHg), MAP (mmHg), RPP (mmHg), RBF/gLKW (ml/min·g), and UT/100gBW in two models of normal and 2K1C ovariectomized rats.

Model

Non-2K1C (control, normotensive)

2K1C (hypertensive)

Subgroup

SBP

MAP

RPP

RBF/gLKW

UT/100 gBW

SBP

MAP

RPP

RBF/gLKW

UT/100 gBW

OVX

6

5

^#

^#

^#

OVX+A779

6

6

^#

^#

^#

OVX+ES

6

5

^#

^#

^#

OVX+ES+A779

5

5

^#

^#

^#

—

0.30

0.81

0.86

0.36

<0.0001

—

0.37

0.29

0.31

0.54

<0.0001

Data are presented as the . The values were derived from one-way ANOVA. Specific contrasts were generated by LSD post hoc comparisons. OVX: ovariectomized; ES: estradiol; LKW: left kidney weight; BW: body weight; UW: uterus weight; KW: kidney weight; SBP: systolic blood pressure; MAP: mean arterial pressure; RPP: renal perfusion pressure; RBF: renal blood flow per gram kidney weight; RVR: renal vascular resistance. Significant difference from nonestradiol groups (). ^#Significant difference from non-2K1C groups ().