The Role of Angiotensin Antagonism in Coronary Plaque Regression: Insights from the Glagovian Model

Figure 1

Stages of vascular remodeling. Atheromatous plaque progression will not affect the lumen area until the 40% threshold has been surpassed. The EEM may compensate the plaque build-up with outward remodeling (positive remodeling). Fibrotic changes of the EEM area may result in the shrinkage of the vessel area, leading to reduced vessel area (negative remodeling).