Could Proteomic Research Deliver the Next Generation of Treatments for Pneumococcal Meningitis?

Figure 2

The hippocampus is a part of the forebrain, located in the medial temporal lobe. The hippocampus is used in storing and processing spatial information. In the rabbit model of pneumococcal meningitis, hippocampal apoptosis was found to be the predominant form of neuronal damage. In humans, apoptosis and pyknosis have been identified in the dentate gyrus of the hippocampus. Apoptosis primarily affects the subgranular zone containing recently divided immature neurons. Pyknosis occurs throughout the dentate granular cell layer.