Sterol Biosynthesis Pathway as Target for Anti-trypanosomatid Drugs
Figure 10
Treatment of promastigotes with ER-119884 induces the accumulation of several lipid droplets in the cytosol, sometimes appearing as an electrondense structure due to osmium tetroxide concentration ((a)-(b), small arrows), and as a classic lipid body surrounded by a phospholipid monolayer ((b), large arrows). At high magnification (stars), it is evident that the structures are completely different, probably indicating a distintic nature of the lipids that accumulate in these inclusions. M, mitochondrion; N, nucleus. All images are reproduced with permission from [37] American Society for Microbiology. Bars, m.
