Sterol Biosynthesis Pathway as Target for Anti-trypanosomatid Drugs
Figure 11
Ultrathin sections of L. amazonensis promastigotes treated with different sterol biosynthesis inhibitors showing severe alterations in the plasma membrane lining (a) the flagellar pocket, (b) the flagellum, and (c)-(d) the cell body. In (d) it is possible to observe a breakdown in the plasma membrane and release of the subpellicular microtubules (arrowhead). Star in (c) shows a classic lipid body. F, flagellum; FP, flagellar pocket; k, kinetoplast; M, mitochondrion. Images are reproduced with permission from [79] (a), and [66] (b), (d) Elsevier. Bars, m (a)–(c) and m (d).
