Sterol Biosynthesis Pathway as Target for Anti-trypanosomatid Drugs
Figure 5
Ultrathin sections of L. amazonensis promastigotes control (a) and treated with azasterols, known inhibitors of the -sterol methyltransferase (b)–(d). (a) General overview of an untreated-parasite showing a normal ultrastructure of the mitochondrion (M), kinetoplast (k), flagellum (F) and nucleus (N). (b)–(d) Treated-parasites presenting severe alterations in the mitochondrion structure such as a disorganization of the internal membranes ((b) and (c), arrowheads) and an intense and evident mitochondrial swelling with loss of the matrix content (b)–(d). Bars m.
