B Cell IgD Deletion Prevents Alveolar Bone Loss Following Murine Oral Infection
Changes in bone levels due to oral infection with P. gingivalis. The distance from the CEJ on the tooth to the ABC of the jaw was measured at 14 buccal sites on the maxillary molars, seven sites on the left (L) and seven on the right (R), with site number 1 located closest to the midline. Each point indicates the mean measurement at that site SEM ( mice). (a) Immune normal BALB/cJ mice showed alveolar bone resorption when infected with P. gingivalis. The distances from the CEJ to the ABC were significantly larger in infected mice than in sham-infected mice () at each of the 14 sites, indicating that alveolar bone resorbed at every measurement site. (b) IgD deficient IgH mice did not show alveolar bone resorption. The distances from the CEJ to the ABC were the same in P. gingivalis-infected mice as in sham-infected mice ().
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