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Interdisciplinary Perspectives on Infectious Diseases
Volume 2010, Article ID 678648, 9 pages
http://dx.doi.org/10.1155/2010/678648
Research Article

COMT Val158Met Polymorphism, Executive Dysfunction, and Sexual Risk Behavior in the Context of HIV Infection and Methamphetamine Dependence

1Department of Psychiatry, University of California San Diego, La Jolla, CA 92103, USA
2San Diego Joint Doctoral Program in Public Health (Health Behavior), San Diego State/University of California, CA 92182, USA
3The Naval Hospital, University of California, San Diego, CA 92055, USA
4The Veterans Affairs San Diego Healthcare System, CA 92161, USA

Received 18 August 2009; Accepted 10 October 2009

Academic Editor: Marylou V. Solbrig

Copyright © 2010 C. A. Bousman et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. Joint United Nations Programme on HIV/AIDS et al., “AIDS epidemic update, 86,” 2006. View at Google Scholar
  2. R. J. Diclemente, C. P. Crittenden, E. Rose et al., “Psychosocial predictors of HIV-associated sexual behaviors and the efficacy of prevention interventions in adolescents at-risk for HIV infection: what works and what doesn't work?” Psychosomatic Medicine, vol. 70, no. 5, pp. 598–605, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  3. J. D. Fortenberry, “Adolescent substance use and sexually transmitted diseases risk: a review,” Journal of Adolescent Health, vol. 16, no. 4, pp. 304–308, 1995. View at Publisher · View at Google Scholar · View at Scopus
  4. B. C. Leigh and R. Stall, “Substance use and risky sexual behavior for exposure to HIV: issues in methodology, interpretation, and prevention,” American Psychologist, vol. 48, no. 10, pp. 1035–1045, 1993. View at Google Scholar · View at Scopus
  5. I. I. Gottesman and T. D. Gould, “The endophenotype concept in psychiatry: etymology and strategic intentions,” American Journal of Psychiatry, vol. 160, no. 4, pp. 636–645, 2003. View at Publisher · View at Google Scholar · View at Scopus
  6. A. W. Stacy, M. D. Newcomb, and S. L. Ames, “Implicit cognition and HIV risk behavior,” Journal of Behavioral Medicine, vol. 23, no. 5, pp. 475–499, 2000. View at Publisher · View at Google Scholar · View at Scopus
  7. R. Gonzalez, J. Vassileva, A. Bechara et al., “The influence of executive functions, sensation seeking, and HIV serostatus on the risky sexual practices of substance-dependent individuals,” Journal of the International Neuropsychological Society, vol. 11, no. 2, pp. 121–131, 2005. View at Publisher · View at Google Scholar · View at Scopus
  8. P. A. Hall, L. J. Elias, and M. Crossley, “Neurocognitive influences on health behavior in a community sample,” Health Psychology, vol. 25, no. 6, pp. 778–782, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  9. E. D. Barker, J. R. Séguin, H. R. White et al., “Developmental trajectories of male physical violence and theft: relations to neurocognitive performance,” Archives of General Psychiatry, vol. 64, no. 5, pp. 592–599, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  10. T. R. Barclay, C. H. Hinkin, S. A. Castellon et al., “Age-associated predictors of medication adherence in HIV-positive adults: health beliefs, self-efficacy, and neurocognitive status,” Health Psychology, vol. 26, no. 1, pp. 40–49, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  11. E. W. Triche, N. Hossain, and M. J. Paidas, “Genetic influences on smoking cessation and relapse in pregnant women,” Journal of Obstetrics and Gynaecology, vol. 28, no. 2, pp. 155–160, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  12. T. Rankinen and C. Bouchard, “Genetics of food intake and eating behavior phenotypes in humans,” Annual Review of Nutrition, vol. 26, pp. 413–434, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  13. M. Tafti, S. Maret, and Y. Dauvilliers, “Genes for normal sleep and sleep disorders,” Annals of Medicine, vol. 37, no. 8, pp. 580–589, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  14. M. R. Melis and A. Argiolas, “Dopamine and sexual behavior,” Neuroscience and Biobehavioral Reviews, vol. 19, no. 1, pp. 19–38, 1995. View at Publisher · View at Google Scholar · View at Scopus
  15. A. Nieoullon, “Dopamine and the regulation of cognition and attention,” Progress in Neurobiology, vol. 67, no. 1, pp. 53–83, 2002. View at Publisher · View at Google Scholar · View at Scopus
  16. J. M. Starr, H. Fox, S. E. Harris, I. J. Deary, and L. J. Whalley, “COMT genotype and cognitive ability: a longitudinal aging study,” Neuroscience Letters, vol. 421, no. 1, pp. 57–61, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  17. S. W. Anderson and D. Tranel, “Neuropsychological consequences of dysfunction in human dorsolateral prefrontal cortex,” in Handbook of Neuropsychology, J. Grafman, Ed., pp. 145–156, Elsevier, Amsterdam, The Netherlands, 2002. View at Google Scholar
  18. A. Bechara, “Risky business: emotion, decision-making, and addiction,” Journal of Gambling Studies, vol. 19, no. 1, pp. 23–51, 2003. View at Publisher · View at Google Scholar · View at Scopus
  19. D. A. Lewis, D. S. Melchitzky, S. R. Sesack, R. E. Whitehead, S. Auh, and A. Sampson, “Dopamine transporter immunoreactivity in monkey cerebral cortex: regional, laminar, and ultrastructural localization,” Journal of Comparative Neurology, vol. 432, no. 1, pp. 119–136, 2001. View at Publisher · View at Google Scholar · View at Scopus
  20. J. Chen, B. K. Lipska, N. Halim et al., “Functional analysis of genetic variation in catechol-O-methyltransferase (COMT): effects on mrna, protein, and enzyme activity in postmortem human brain,” American Journal of Human Genetics, vol. 75, no. 5, pp. 807–821, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  21. J. H. Barnett, P. B. Jones, T. W. Robbins, and U. Müller, “Effects of the catechol-O-methyltransferase Val158Met polymorphism on executive function: a meta-analysis of the Wisconsin Card Sort Test in schizophrenia and healthy controls,” Molecular Psychiatry, vol. 12, no. 5, pp. 502–509, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  22. S.-J. Tsai, C.-J. Hong, Y. W.-Y. Yu, and T.-J. Chen, “Association study of catechol-O-methyltransferase gene and dopamine D4 receptor gene polymorphisms and personality traits in healthy young Chinese females,” Neuropsychobiology, vol. 50, no. 2, pp. 153–156, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  23. M. Reuter and J. Hennig, “Association of the functional catechol-O-methyltransferase VALI58MET polymorphism with the personality trait of extraversion,” NeuroReport, vol. 16, no. 10, pp. 1135–1138, 2005. View at Publisher · View at Google Scholar · View at Scopus
  24. L. Hosák, J. Libiger, J. Cizek, M. Beránek, and E. Cermáková, “The COMT Val158Met polymorphism is associated with novelty seeking in Czech methamphetamine abusers: preliminary results,” Neuroendocrinology Letters, vol. 27, no. 6, pp. 799–802, 2006. View at Google Scholar · View at Scopus
  25. E. M. Drabant, A. R. Hariri, A. Meyer-Lindenberg et al., “Catechol O-methyltransferase val158met genotype and neural mechanisms related to affective arousal and regulation,” Archives of General Psychiatry, vol. 63, no. 12, pp. 1396–1406, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  26. L. McKusick, T. J. Coates, S. F. Morin, L. Pollack, and C. Hoff, “Longitudinal predictors of reductions in unprotected anal intercourse among gay men in San Francisco: the AIDS Behavioral Research Project,” American Journal of Public Health, vol. 80, no. 8, pp. 978–983, 1990. View at Google Scholar · View at Scopus
  27. A. T. Beck, Depression Causes and Treatment, University of Pennsylvania Press, Philadelphia, Pa, USA, 1972.
  28. R. K. Heaton and P. Staff, “Wisconsin Card Sorting Test: Computerized Version 2. Research Edition,” 1993. View at Google Scholar
  29. N. A. DeFilippis and P. Staff, “Category Test: Computer Version,” 1993. View at Google Scholar
  30. Army Individual Test Battery, Manual of Directions and Scoring, Adjunct General's Office, War Deparment, Washington, DC, USA, 1944.
  31. R. K. Heaton, I. Grant, N. Butters et al., “The HNRC 500—neuropsychology of HIV infection at different disease stages. HIV Neurobehavioral Research Center,” Journal of the International Neuropsychological Society, vol. 1, no. 3, pp. 231–251, 1995. View at Google Scholar · View at Scopus
  32. C. L. Carey, S. P. Woods, R. Gonzalez et al., “Predictive validity of global deficit scores in detecting neuropsychological impairment in HIV infection,” Journal of Clinical and Experimental Neuropsychology, vol. 26, no. 3, pp. 307–319, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  33. R. M. Baron and D. A. Kenny, “The moderator-mediator variable distinction in social psychological research. Conceptual, strategic, and statistical considerations,” Journal of Personality and Social Psychology, vol. 51, no. 6, pp. 1173–1182, 1986. View at Publisher · View at Google Scholar · View at Scopus
  34. S. C. Kalichman, T. Heckman, and J. A. Kelly, “Sensation seeking as an explanation for the association between substance use and HIV-related risky sexual behavior,” Archives of Sexual Behavior, vol. 25, no. 2, pp. 141–154, 1996. View at Publisher · View at Google Scholar · View at Scopus
  35. S. C. Kalichman, J. R. Johnson, V. Adair, D. Rompa, K. Multhauf, and J. A. Kelly, “Sexual sensation seeking: scale development and predicting AIDS-risk behavior among homosexually active men,” Journal of Personality Assessment, vol. 62, no. 3, pp. 385–397, 1994. View at Google Scholar · View at Scopus
  36. J. T. Parsons and P. N. Halkitis, “Sexual and drug-using practices of HIV-positive men who frequent public and commercial sex environments,” AIDS Care, vol. 14, no. 6, pp. 815–826, 2002. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  37. C. S. Hendershot, S. A. Stoner, W. H. George, and J. Norris, “Alcohol use, expectancies, and sexual sensation seeking as correlates of HIV risk behavior in heterosexual young adults,” Psychology of Addictive Behaviors, vol. 21, no. 3, pp. 365–372, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  38. S. M. Noar, C. Cole, and K. Carlyle, “Condom use measurement in 56 studies of sexual risk behavior: review and recommendations,” Archives of Sexual Behavior, vol. 35, no. 3, pp. 327–345, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  39. V. E. Golimbet, M. V. Alfimova, I. K. Gritsenko, and R. P. Ebstein, “Relationship between dopamine system genes and extraversion and novelty seeking,” Neuroscience and Behavioral Physiology, vol. 37, no. 6, pp. 601–606, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  40. V. S. Mattay, T. E. Goldberg, F. Fera et al., “Catechol O-methyltransferase val158-met genotype and individual variation in the brain response to amphetamine,” Proceedings of the National Academy of Sciences of the United States of America, vol. 100, no. 10, pp. 6186–6191, 2003. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus