Cryptococcus neoformans as a Model for Radioimmunotherapy of Infections

Figure 1

Efficacy of RIT of CN with 213Bi- and 188Re- labeled mAbs: (a, b) Kaplan-Meier survival curves for A/JCr mice infected IV with 10⁵  C. neoformans cells 24 hr prior to treatment with 50–200 μCi 188Re- (a) or 213Bi-labeled (b) mAbs. Animals injected with PBS (phosphate buffered saline) or 50 μg “cold” 18B7 served as controls; (c) treatment of CN biofilms in vitro with 213Bi- (left panel ) or 188Re- (right panel) labeled 18B7 mAb; adapted from [3, 12].

(a)

(b)

(c)