Cryptococcus neoformans as a Model for Radioimmunotherapy of Infections
Figure 2
Toxicity of RIT in mice with CN infections. (a) Platelet counts in RIT-treated mice. CN-infected A/JCr mice received various doses of Bi-18B7. A “0” indicates infected nontreated mice. Mice treated with 200 and 250 μCi Bi-18B7 died by day 7 posttreatment; (b–d) micrographs of hematoxylin-and-eosin-stained lungs from BALB/c mice infected IT with CN and treated with radiolabeled mAbs. Mice were sacrificed 5 months after RIT: (b) infected control group (no RIT); (c) 200 μCi Bi-18B7; (d) 200 μCi Re-18B7; adapted from [13].
