Cryptococcus neoformans as a Model for Radioimmunotherapy of Infections
Figure 4
Contribution of different radiobiological effects to RIT of CN with Bi-18B7 and Re-18B7 mAbs. (a–c) show CFUs and PI permeability for: (a) external gamma radiation; (b) Re-18B7; (c) Bi-18B7. (d–f) show CFUs and apoptosis levels by FLICA: (d) external gamma radiation; (e) Re-18B7; (f) Bi-18B7. (g–h) show contribution of “cross-fire” and “direct hit” towards killing of CN cells: (g) “cross-fire” and “direct hit” for Bi-18B7; (h) “cross-fire” and “direct hit” for Re-18B7. The contribution of “direct hit” towards cell killing was calculated by subtracting percentage of cells killed by “cross-fire” from percentage of cells killed by RIT; adapted from[19, 21].
