Immune Modulation as Adjunctive Therapy for Pneumocystis pneumonia
Figure 2
SSZ enhances CD4+-T-cell-dependent AM phagocytosis of Pc. BAL cells were collected from PBS- and SSZ-treated mice at day 18 (17/18) post-reconstitution. Cells were stained with antibodies specific for CD11c (green) and Pneumocystis (red). Imaging flow cytometry was used to measure Pneumocystis internalization by AMs. Representative images of bright field (BF), CD11c, Pc, and merged CD11c/Pc are shown for PBS- (a) or SSZ-treated (b) mice following immune reconstitution.
