Natural History and Factors Associated with Early and Delayed Mortality in HIV-Infected Patients Treated of Tuberculosis under Directly Observed Treatment Short-Course Strategy: A Prospective Cohort Study in India

Table 3

Cox regression analysis of factors associated with death after three months of anti-tuberculosis treatment.

	Overall		Males		Females
	HR (95% CI)	𝑃 value	HR (95% CI)	𝑃 value	HR (95% CI)	𝑃 value
Age (years)
<35	1		1		1
>35	0.92 (0.66–1.29)	0.633	1.14 (0.76–1.71)	0.523	0.61 (0.31–1.18)	0.143
Literacy
Yes	1		1		1
No	1.28 (0.9–1.84)	0.172	1.04 (0.69–1.56)	0.868	2.78 (0.98–7.91)	0.055
Homeless
No	1		1		1
Yes	1.8 (0.86–3.76)	0.121	1.96 (0.69–5.53)	0.206	1.67 (0.56–4.94)	0.358
Community
ST/SC	1.87 (1.32–2.64)	<0.001	2.39 (1.54–3.69)	<0.001	1.49 (0.8–2.78)	0.208
OC/BC	1		1		1
CD4+ lymphocyte count*
<100	2.85 (1.61–5.04)	<0.001	2.53 (1.22–5.23)	0.012	3.23 (1.27–8.19)	0.014
100–250	1.58 (0.89–2.82)	0.121	1.43 (0.68–2.98)	0.344	1.72 (0.67–4.39)	0.258
>250	1		1		1
Previous ATT
No (category I)	1		1		1
Yes (category II)	1.61 (1.09–2.39)	0.017	1.56 (0.99–2.45)	0.055	1.69 (0.78–3.67)	0.184
Sputum AFB
Negative	1		1		1
Positive	1.54 (1.08–2.18)	0.016	1.92 (1.26–2.91)	0.002	1.08 (0.53–2.21)	0.836
ART before ATT
No	1		1		1
Yes	0.76 (0.52–1.1)	0.147	0.91 (0.58–1.43)	0.688	0.54 (0.26–1.11)	0.094
Gender
Male	1.1 (0.76–1.6)	0.618
Female	1

AFB: acid fast bacilli; ART: antiretroviral therapy; ATT: anti-tuberculosis treatment; CI: confidence interval; HR: hazard ratio. *cells/mm³.