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Interdisciplinary Perspectives on Infectious Diseases
Volume 2012, Article ID 646480, 5 pages
http://dx.doi.org/10.1155/2012/646480
Clinical Study

In Vitro Activities of Ertapenem and Imipenem against Clinical Extended Spectrum Beta-Lactamase-Producing Enterobacteriaceae Collected in Military Teaching Hospital Mohammed V of Rabat

1Department of Bacteriology, Military Teaching Hospital Mohammed V and Faculty of Medicine and Pharmacy, Mohammed V University, Souissi, Rabat, Morocco
2Laboratory of Biostatistics, Faculty of Medicine and Pharmacy, Mohammed V University, Souissi, Rabat, Morocco
3Study Research Group for Antibiotic Resistance and Bacterial Infections, Faculty of Medicine and Pharmacy, Mohammed V University, Souissi, Rabat, Morocco

Received 5 February 2012; Accepted 2 May 2012

Academic Editor: Abiola C. Senok

Copyright © 2012 M. Elouennass et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective. To study the sensitivity level of extended spectrum beta-lactamase-producing Enterobacteriaceae to Carbapenems (Imipenem, Ertapenem) marketed in Morocco and discusses the place of Ertapenem in the treatment of extended spectrum-beta-lactamase-producing. Materials and Methods. A retrospective study of 110 extended spectrum beta-lactamase-producing Enterobacteriaceae. Isolates obtained from blood cultures, superficial and deep pus, and catheters were conducted. The minimum inhibitory concentrations of Imipenem and Ertapenem were done by the E-test. The modified Hodge test was conducted for resistant or intermediate strains. Results. 99.1% of isolates were susceptible to Imipenem. For Ertapenem, 4 were resistant and 4 intermediate. The modified Hodge test was positive for all 08 isolates. A minimum inhibitory concentration comparison of K. pneumoniae, E. cloacae, and E. coli for Imipenem has noted a significant difference between E. cloacae on one hand and E. coli, K. pneumoniae on the other hand ( 𝑃 < 0 . 0 1 ). No significant difference was noted for minimum inhibitory concentration of Ertapenem. Conclusion. Our results confirm in vitro effectiveness of Ertapenem against extended spectrum beta-lactamase-producing Enterobacteriaceae as reported elsewhere. However, the emergence of resistance to Carbapenems revealed by production of carbapenemases in this study confirmed a necessary bacteriological documented infection before using Ertapenem.