Impact of Inappropriate Empiric Antimicrobial Therapy on Mortality of Septic Patients with Bacteremia: A Retrospective Study

Table 6

Multivariate analysis of factors associated with inappropriate first-dose and 24-hour antimicrobial therapy.

Factors	Total n (%)	First dose	OR (95% CI)	24-hour dose	OR (95% CI)
		𝑃 value		𝑃 value
Nosocomial infection	81 (35.4)	0.225	1.86 (0.68–5.04)	0.018	3.31 (1.22–8.93)
Neutropenia	41 (17.9)	0.022	2.94 (0.16–7.14)	0.156	0.51 (0.20–1.29)
WBC < 4000 per uL	40 (17.5)	0.016	2.45 (1.18–5.08)	0.121	1.81 (0.86–3.84)
Platelet < 100,000 per uL	109 (47.6)	0.013	2.42 (1.20–4.88)	0.055	2.13 (0.98–4.62)
Drug-resistant gram-positive bacteria	17 (7.4)	<0.001	6.03 (2.35–15.43)	<0.001	6.14 (2.30–16.37)
Drug-resistant gram-negative bacteria	74 (32.3)	<0.001	10.76 (3.98–29.09)	<0.001	8.50 (3.10–23.32)

Other variables: Age ≥ 65 years, neutropenia, chronic renal failure, albumin ≤ 3.2 g/dL, serum cortisol ≥ 35 mg/dL, co-morbidity ≥ 4, APACHE II score ≥ 25, septic shock, congestive heart failure, liver failure, respiratory infection, genitourinary infection, antimicrobial mono-therapy, and colistin usage.