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Interdisciplinary Perspectives on Infectious Diseases
Volume 2013 (2013), Article ID 839456, 8 pages
http://dx.doi.org/10.1155/2013/839456
Clinical Study

Prospective Trial of a Novel Nomogram to Achieve Updated Vancomycin Trough Concentrations

1Department of Pharmacy Practice, Shenandoah University, 1775 North Sector Court, Winchester, VA 22601, USA
2Department of Pharmacy, Winchester Medical Center, 1840 Amherst Street, Winchester, VA 22601, USA
3Department of Biopharmaceutical Sciences, Shenandoah University, 1775 North Sector Court, Winchester, VA 22601, USA

Received 24 July 2013; Accepted 6 August 2013

Academic Editor: Dino Vaira

Copyright © 2013 Amber R. Wesner et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose. To determine if the use of a novel vancomycin nomogram predicts dosing regimens that achieve target trough concentrations equal to or more accurate than dosing regimens calculated using traditional pharmacokinetic calculations, evaluate the incidence of subtherapeutic and supratherapeutic troughs, and assess pharmacist's impressions of the nomogram. Methods. Prospective, open-label study in 473 patients who had a new order for vancomycin and were >18 years of age and ≤120 kg. Patients were randomized to the active group, dosed using the nomogram, or to the control group, dosed using traditional pharmacokinetic calculations already in place at our institution. Results. Patients dosed via nomogram were within the appropriate trough range in 44% of cases compared to 33% in the control group (). Vancomycin troughs less than 10 mcg/mL were significantly decreased with the use of nomogram (). Incidence of supratherapeutic troughs, greater than 20 mcg/mL, was not significantly different between groups (), and pharmacists agreed that the nomogram was easy to use and saved their time. Conclusions. A novel vancomycin nomogram was prospectively validated and found to be more effective than traditional pharmacokinetic dosing. The nomogram is being implemented as the standard dosing protocol at our institution.