Prospective Trial of a Novel Nomogram to Achieve Updated Vancomycin Trough Concentrations

Table 1

Characteristics of study subjects.

Characteristics	Nomogram (𝑛=221)	Traditional (𝑛=252)	P value
Age (yrs)^a	58 ± 18	61 ± 17	0.040
Actual body weight (kg)^a	83.6 ± 18.7	83.9 ± 17.4	0.873
Ideal body weight (kg)^a	63.5 ± 10.6	65.5 ± 11.6	0.051
Height (in)^a	66.8 ± 3.9	67.5 ± 4.3	0.051
Initial SCr (mg/dL)^a	0.96 ± 0.31	1.0 ± 0.38	0.143
Change in SCr (%)^a	14 ± 11.6	15 ± 11.5	0.389
Intensive care unit admission: n (%)	40 (18)	57 (23)	0.271
Gender: n (% Females)	107 (48)	105 (42)	0.168
Patients stratified by creatinine clearance: n (%)
≥100 mL/min	79 (35.7)	59 (23.4)
80–99 mL/min	27 (12.2)	46 (18.3)
60–79 mL/min	53 (24.0)	59 (23.4)
40–59 mL/min	42 (19.0)	51 (20.2)
20–39 mL/min	20 (9.0)	37 (14.7)
≤19 mL/min	0	0
Patients stratified by diagnosis: n (%)
Pneumonia	66 (29.9)	76 (30.2)
Cellulitis	68 (30.8)	72 (28.6)
Bacteremia	32 (14.5)	32 (12.7)
Osteomyelitis	11 (5.0)	13 (5.2)
Abscess	15 (6.8)	11 (4.4)
Empiric	10 (4.5)	16 (6.3)
Urinary tract infection	2 (0.9)	9 (3.6)
Respiratory failure	3 (1.4)	6 (2.4)
Miscellaneous: endocarditis, meningitis, febrile neutropenia, diverticulitis, and wounds	14 (6.3)	17 (6.7)

 ^aMean ± standard deviation.
SCr: serum creatinine.