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Interdisciplinary Perspectives on Infectious Diseases
Volume 2014, Article ID 576107, 8 pages
http://dx.doi.org/10.1155/2014/576107
Research Article

Frequencies of Blood Group Systems MNS, Diego, and Duffy and Clinical Phases of Carrion’s Disease in Amazonas, Peru

1Institute of Tropical Medicine Daniel A. Carrion, Faculty of Medicine, Major National University of San Marcos, Lima, Peru
2Genetics and Molecular Biology Center, Faculty of Medicine, University of San Martin of Porres, Lima, Peru
3Institute of Biological Chemistry, Microbiology and Biotechnology, Faculty of Pharmacy and Biochemistry, Major National University of San Marcos, Lima, Peru
4Peruvian Ministry of Health (MINSA), Direction of the Sub Region of Health Bagua, Bagua Grande, Amazonas, Peru
5Peruvian Ministry of Health (MINSA), General Direction of Environmental Health (DIGESA), Lima, Peru

Received 31 August 2013; Revised 7 February 2014; Accepted 20 February 2014; Published 31 March 2014

Academic Editor: Jose G. Estrada-Franco

Copyright © 2014 Oscar Acosta et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Carrion’s disease (CD), is a human bartonellosis, that is, endemic in the Andes of Peru, Ecuador, and Colombia. Bartonella bacilliformis, a native hemotrophic bacteria, is the causative agent of CD, and the interaction with the host could have produced changes in the gene frequencies of erythrocyte antigens. The goal here is to investigate the relationship between allele frequencies of blood group systems MNS, Diego, and Duffy and the clinical phases of CD, within a genetic context. In this associative and analytical study, 76 individuals from Bagua Grande, the province of Utcubamba, and the department of Amazonas in Peru, were enrolled. Forty of them resided in Tomocho-Collicate-Vista Hermosa area (high prevalence of cases in chronic phase, verrucous, or eruptive phase, without previous acute phase). Thirty-six individuals were from the area of Miraflores (high prevalence of cases in acute phase only) and were evaluated for blood group systems MNS, Diego, and Duffy. This study constitutes one of the first attempts at evaluating the genetic factors and clinical phases of CD. No significant statistical differences between allele frequencies of blood groups MNS, Diego, and Duffy and the prevalence of chronic and acute phases were detected in the two areas of Amazonas, Peru.