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Interdisciplinary Perspectives on Infectious Diseases
Volume 2017, Article ID 7463489, 6 pages
https://doi.org/10.1155/2017/7463489
Research Article

Serum Ferritin: A Backstage Weapon in Diagnosis of Dengue Fever

1Woodlands Hospital, 8/5 Alipore Road, Alipore, Kolkata West Bengal 700027, India
2Department of Tropical Medicine, School of Tropical Medicine, 108 Chittaranjan Avenue, Kolkata, West Bengal 700073, India
3Medical Services, Biocon Limited, Bengaluru 560100, India

Correspondence should be addressed to Soumyabrata Roy Chaudhuri; moc.liamg@scimedaca.aymuos

Received 3 May 2017; Revised 8 August 2017; Accepted 23 August 2017; Published 2 October 2017

Academic Editor: Massimiliano Lanzafame

Copyright © 2017 Soumyabrata Roy Chaudhuri et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Aims. This retrospective study evaluates ferritin as a surrogate marker for dengue infection (NS1 and IgM negative stage) as opposed to other febrile illnesses of infective or inflammatory etiology (OFI). Methodology. Data of all patients admitted to medical ward and medical ITU during the dengue outbreak were collected. Patients admitted between 5 and 10 days of febrile illness without a diagnosis were included. Patients with NS1 positivity (Days 2–8) and/or positive IgM for dengue (Days 6–10) were considered to be dengue cases and those with other confirmed diagnoses were considered in the OFI group. Ferritin, CRP, TC of WBC, platelet count, SGOT, SGPT, and albumin levels were analysed for both groups. Results. We examined 30 cases of clinically and serologically confirmed dengue fever and 22 cases of OFI. Ferritin level in dengue cohort was significantly higher than the OFI group (). The best cut-off for ferritin level to differentiate dengue from OFI was found to be 1291. The sensitivity at this cut-off is 82.6% and the specificity at this cut-off is 100%. Conclusion. Ferritin may serve as a significant marker for differentiating between dengue fever and OFI, in absence of a positive NS1 antigen or a positive IgM antibody for dengue.