Interdisciplinary Perspectives on Infectious Diseases / 2019 / Article / Tab 4

Research Article

Assessing the Impact of Isoniazid Preventive Therapy (IPT) on Tuberculosis Incidence and Predictors of Tuberculosis among Adult Patients Enrolled on ART in Nekemte Town, Western Ethiopia: A Retrospective Cohort Study

Table 4

Predictors of tuberculosis risk, multivariate analysis by Cox proportional hazard model of PLWHA at Nekemte referral hospital and Nekemte Health center followed from September 2009-September 2012.

Variables (n=600)CategoryUnadjusted HR(95%CIP-valueAdjusted HR(95%CIP-value

Age<=30ReferentReferent
31-400.47(0.23-0.95)0.035∗0.47(0.23-1.05)0.06#
41-501.05(0.46-2.38)0.921.05(0.46-2.38)0.072#
>502.9(1.13-7.5)0.027∗2.9(1.13-7.5)0.08#

CD4 Count>500Referent
351-5001.25(0.314-5.16)0.7491.25(0.89 -5.16)0.68#
201-3504.9(1.6-14.6)0.005∗4.9(1.6-14.6)0.007
<=20017.5 (6.15-50)<0.001∗17.5 (6.15-50)<0.001

SexMaleReferent
Female1.095(0.83-0.525

BMI>=18.5Referentreferent
<18.53.13(1.77-5.53)<0.001∗3.13(1.77-5.53)0.042

Weight>50ReferentReferent
<=501.72(1.28 -2.28)0.001∗1.72(1.28 -2.28)0.041

WHO StageI/IIReferentReferent
III/IV3.22(0.96-4.56)0.08∗3.22(1.96-4.56)0.037

Functional StatusWorkingReferentReferent
Ambulatory/Bedridden3.38(1.9-5.96)<0.001∗3.38(1.9-5.96)0.022

Cotrimoxazole TreatmentYesReferentReferent
No4.21(2.42-7.4)<0.001∗4.21(2.42-7.4)<0.001

Previous TBNoReferent
Yes1.43(0.56-3.58)0.45

Opportunistic InfectionNoReferentReferent
Yes1.02(0.51-2.02)0.06∗1.02(0.51-2.02)0.061#

Cohort GroupYesReferentReferent
No2.5(1.3-4.9).007∗2.5(1.3-4.9)0.03

All candidate variables for multivariate analysis.
#Lost statistical significance in multivariate analysis.

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